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公开(公告)号:US10675452B2
公开(公告)日:2020-06-09
申请号:US15124400
申请日:2015-03-05
发明人: Andreas Syrek , Marc Peuker , Mathias Bertl , Martin Preininger , Emir Jelovac , Ryan P. Simmers
摘要: A micro-needle device for delivering a dental local anesthetic that includes a micro-needle array and a hollow spheroid shaped container. The micro-needle array has a base and two or more elongate micro-needles. The elongate micro-needles have an interior surface defining an opening through the elongate micro-needle and the base has a first major surface and a second major surface through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface, where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle. This allows the dental local anesthetic to flow from the volume of the micro-needle device through the opening of the two or more of the elongate micro-needle.
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公开(公告)号:US20150246214A1
公开(公告)日:2015-09-03
申请号:US14433234
申请日:2013-11-14
发明人: Ryan P. Simmers
IPC分类号: A61M37/00
CPC分类号: A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要: An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. A method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.
摘要翻译: 一种用于将微针装置施加到皮肤表面的施加器(100),包括包括微针阵列(107)的第一部分(102)和经由连接器(106)联接到第一部分的第二部分(104)。 连接器可以被配置为通过从连接器完整的第一状态变为第二状态而产生或断裂,其中当将阈值施加力施加到第一部分和第二部分中的至少一个时,连接器产生或断裂 第二部分在相对于第一部分基本垂直的方向上。 一种方法可以包括在基本上垂直于第一部分的方向上按压施加器,以将微针阵列压入皮肤表面,直到达到或超过阈值施加力并且连接器被改变到其第二状态。
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公开(公告)号:US11964248B2
公开(公告)日:2024-04-23
申请号:US17364547
申请日:2021-06-30
发明人: Jeffrey R. Janssen , Mark F. Schulz , Scott D. Gullicks , Dennis R. Keicher , Bruce R. Broyles , Ryan P. Simmers , Jameel R. Qiblawi
IPC分类号: B01F35/00 , A61C5/64 , B01F27/09 , B01F27/1125 , B01F33/501 , B01F35/52 , B01F35/88 , B05C17/005 , B05C17/01 , B05C17/015 , B65D81/32 , A61C5/68 , B01F101/19
CPC分类号: B01F35/88 , A61C5/64 , B01F27/092 , B01F27/1125 , B01F33/5011 , B01F33/50114 , B01F35/522 , B05C17/00553 , B05C17/00566 , B05C17/0103 , B05C17/015 , B65D81/325 , A61C5/68 , B01F2101/19 , B05C17/0133 , B05C17/014
摘要: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.
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公开(公告)号:US09789299B2
公开(公告)日:2017-10-17
申请号:US14433234
申请日:2013-11-14
发明人: Ryan P. Simmers
IPC分类号: A61M37/00
CPC分类号: A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要: An applicator (100) for applying a microneedle device to a skin surface comprising a first portion (102) comprising a microneedle array (107), and a second portion (104) coupled to the first portion via a connector (106). The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. A method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.
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公开(公告)号:US11084008B2
公开(公告)日:2021-08-10
申请号:US16130776
申请日:2018-09-13
发明人: Jeffrey R. Janssen , Mark F. Schulz , Scott D. Gullicks , Dennis R. Keicher , Bruce R. Broyles , Ryan P. Simmers , Jameel R. Qiblawi
IPC分类号: B01F15/00 , B01F15/04 , A61C5/64 , B01F7/00 , B01F13/00 , B05C17/005 , B05C17/01 , B05C17/015 , B65D81/32 , A61C5/68
摘要: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.
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公开(公告)号:US20190009234A1
公开(公告)日:2019-01-10
申请号:US16130776
申请日:2018-09-13
发明人: Jeffrey R. Janssen , Mark F. Schulz , Scott D. Gullicks , Dennis R. Keicher , Bruce R. Broyles , Ryan P. Simmers , Jameel R. Qiblawi
IPC分类号: B01F15/04 , B65D81/32 , B05C17/015 , A61C5/64 , B01F7/00 , B05C17/01 , B05C17/005 , B01F15/00 , B01F13/00 , A61C5/68
摘要: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.
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公开(公告)号:US09782574B2
公开(公告)日:2017-10-10
申请号:US14433208
申请日:2013-10-07
发明人: Ryan P. Simmers
IPC分类号: A61M37/00
CPC分类号: A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要: An applicator (100) for applying a microneedle device to a skin surface. The applicator can include a microneedle device (106), a housing (102), and a connecting member (110). The connecting member can be configured to allow the microneedle device to move between: (i) a first position in which at least a portion of the microneedle device extends beyond the housing; and (ii) a second position in which the microneedle device is recessed within the housing when a threshold application force is applied to the microneedle device in a direction substantially perpendicular with respect to the microneedle device.
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公开(公告)号:US20170173316A1
公开(公告)日:2017-06-22
申请号:US15124400
申请日:2015-03-05
发明人: Andreas Syrek , Marc Peuker , Mathias Bertl , Martin Preininger , Emir Jelovac , Ryan P. Simmers
IPC分类号: A61M37/00
摘要: A micro-needle device (100, 200, 300) for delivering a dental local anesthetic that includes a micro-needle array (102, 202, 302) and a hollow spheroid shaped container (108, 208, 308). The micro-needle array has a base (104, 204, 304)and two or more of an elongate micro-needle (106, 206, 306). The elongate micro-needle has an interior surface (110, 210, 310) defining an opening (112, 212, 312) through the elongate micro-needle and the base has a first major surface (114, 214, 314) and a second major surface (116, 216, 316) through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface (120, 220, 320), where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle. This allows the dental local anesthetic to flow from the volume of the micro-needle device through the opening of the two or more of the elongate micro-needle.
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公开(公告)号:US20150352295A1
公开(公告)日:2015-12-10
申请号:US14759757
申请日:2014-01-07
CPC分类号: A61M5/5086 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2205/106
摘要: An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user.
摘要翻译: 用于将微针装置施加到皮肤上的涂抹器和方法。 施加器可以包括壳体和与壳体可滑动地接合的往复运动支撑结构。 往复式支撑结构可以具有多个对准脚。 如果对准脚不均匀对准,施加器可以具有防止致动的锁定机构。 施用器可以包括能够计数施加器已经经历的使用周期数并向用户提供反馈的装置寿命指示器。 涂抹器可以包括剂量定时器,其能够确定在致动装置之后已经经过的时间并向用户提供反馈。
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公开(公告)号:US20240226835A1
公开(公告)日:2024-07-11
申请号:US18613912
申请日:2024-03-22
发明人: Jeffrey R. Janssen , Mark F. Schulz , Scott D. Gullicks , Dennis R. Keicher , Bruce R. Broyles , Ryan P. Simmers , Jameel R. Qiblawi
IPC分类号: B01F35/88 , A61C5/64 , A61C5/68 , B01F27/09 , B01F27/1125 , B01F33/501 , B01F35/52 , B01F101/19 , B05C17/005 , B05C17/01 , B05C17/015 , B65D81/32
CPC分类号: B01F35/88 , A61C5/64 , B01F27/092 , B01F27/1125 , B01F33/5011 , B01F33/50114 , B01F35/522 , B05C17/00553 , B05C17/00566 , B05C17/0103 , B05C17/015 , B65D81/325 , A61C5/68 , B01F2101/19 , B05C17/0133 , B05C17/014
摘要: Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.
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