公开(公告)号：US20150147327A1

公开(公告)日：2015-05-28

申请号：US14551792

申请日：2014-11-24

Applicant: ABBVIE INC.

Inventor： Chengbin WU ,  Tariq GHAYUR ,  Richard W. DIXON ,  Jochen G. SALFELD

IPC: C07K16/46 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

公开(公告)号：US20150086554A1

公开(公告)日：2015-03-26

申请号：US14524479

申请日：2014-10-27

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Tariq GHAYUR ,  Richard W. DIXON ,  Jochen G. SALFELD

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

公开(公告)号：US20130195754A1

公开(公告)日：2013-08-01

申请号：US13847862

申请日：2013-03-20

Applicant: ABBVIE INC.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质以及它们在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。

公开(公告)号：US20170340737A1

公开(公告)日：2017-11-30

申请号：US15457264

申请日：2017-03-13

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Richard W. DIXON ,  Jonathan P. BELK ,  Hua YING ,  Maria A. ARGIRIADI ,  Carolyn A. CUFF ,  Paul R. HINTON ,  Shankar KUMAR ,  Terry L. MELIM ,  Yan CHEN

IPC: A61K45/06 ,  C07K16/24 ,  A61K39/395 ,  C07K14/47 ,  A61K38/00

CPC classification number: A61K45/06 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/47 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：US20140377858A1

公开(公告)日：2014-12-25

申请号：US14290527

申请日：2014-05-29

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Tariq GHAYUR ,  Richard W. DIXON ,  Jochen G. SALFELD

IPC: C07K16/46

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

公开(公告)号：US20140212925A1

公开(公告)日：2014-07-31

申请号：US14109606

申请日：2013-12-17

Applicant: AbbVie, Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20140212379A1

公开(公告)日：2014-07-31

申请号：US14107988

申请日：2013-12-16

Applicant: AbbVie, Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 结合IL-1α和IL-1和bgr的蛋白质 描述其用于治疗，预防和诊断IL-1相关疾病和用于检测IL-1α和IL-1和bgr的组合物和方法中的用途; 在细胞，组织，样品和组合物中。