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公开(公告)号：US09828379B2
公开(公告)日：2017-11-28
申请号：US14902324
申请日：2014-07-01
Applicant: Abide Therapeutics, Inc.
Inventor： Todd K. Jones , Justin S. Cisar , Cheryl A. Grice , Dong-Hui Wang , Olivia D. Weber
IPC: C07D487/04 , C07D519/00 , A61K31/407
CPC classification number: C07D487/04 , C07D519/00
Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
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公开(公告)号：US09771341B2
公开(公告)日：2017-09-26
申请号：US15072229
申请日：2016-03-16
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Olivia D. Weber , Dong-Hui Wang
IPC: C07D295/205 , C07D207/08 , C07D207/12 , C07D295/26 , C07D211/38 , C07D211/58 , C07D207/14 , C07D211/14 , C07D498/08 , C07D211/62 , C07D403/04 , C07D401/04 , C07D417/04 , C07D487/04 , C07D471/10 , C07D265/30 , C07D207/16
CPC classification number: C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US11129827B2
公开(公告)日：2021-09-28
申请号：US16431632
申请日：2019-06-04
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US20150080364A1
公开(公告)日：2015-03-19
申请号：US14383076
申请日：2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Insititute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D487/04 , C07D491/107 , C07D471/04 , C07D405/14 , C07D413/12
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。
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公开(公告)号：US20210386734A1
公开(公告)日：2021-12-16
申请号：US17412102
申请日：2021-08-25
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J.M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61P25/04 , A61K31/506
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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Patent Agency Ranking
公开(公告)号：US10350205B2
公开(公告)日：2019-07-16
申请号：US15919113
申请日：2018-03-12
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US20190282568A1
公开(公告)日：2019-09-19
申请号：US16431632
申请日：2019-06-04
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J.M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US10323038B2
公开(公告)日：2019-06-18
申请号：US15777201
申请日：2016-11-18
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. Grice , Todd K. Jones , Katharine K. Duncan , Justin S. Cisar , Jeffrey E. Merit , Olivia D. Weber
IPC: C07D487/10 , C07D487/04 , C07D471/10 , C07D519/00 , C07D403/06 , C07D491/08 , C07D231/40 , C07D231/38 , C07D403/12 , C07D417/12 , C07D401/12 , C07D413/12 , C07D498/08
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US10030020B2
公开(公告)日：2018-07-24
申请号：US15593239
申请日：2017-05-11
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Olivia D. Weber , Daniel J. Buzard , Michael B. Shaghafi
IPC: C07D471/10 , C07D519/00
Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US09994537B2
公开(公告)日：2018-06-12
申请号：US15672165
申请日：2017-08-08
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Olivia D. Weber , Dong-Hui Wang
IPC: C07D295/205 , C07D207/08 , C07D471/10 , C07D417/04 , C07D403/04 , C07D401/04 , C07D295/26 , C07D265/30 , C07D207/12 , C07D211/38 , C07D211/58 , C07D207/14 , C07D211/14 , C07D498/08 , C07D211/62 , C07D487/04 , C07D207/16
CPC classification number: C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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