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公开(公告)号：US09828379B2
公开(公告)日：2017-11-28
申请号：US14902324
申请日：2014-07-01
Applicant: Abide Therapeutics, Inc.
Inventor： Todd K. Jones , Justin S. Cisar , Cheryl A. Grice , Dong-Hui Wang , Olivia D. Weber
IPC: C07D487/04 , C07D519/00 , A61K31/407
CPC classification number: C07D487/04 , C07D519/00
Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
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公开(公告)号：US09771341B2
公开(公告)日：2017-09-26
申请号：US15072229
申请日：2016-03-16
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Olivia D. Weber , Dong-Hui Wang
IPC: C07D295/205 , C07D207/08 , C07D207/12 , C07D295/26 , C07D211/38 , C07D211/58 , C07D207/14 , C07D211/14 , C07D498/08 , C07D211/62 , C07D403/04 , C07D401/04 , C07D417/04 , C07D487/04 , C07D471/10 , C07D265/30 , C07D207/16
CPC classification number: C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US09567302B2
公开(公告)日：2017-02-14
申请号：US14383076
申请日：2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/496 , A61K31/454 , C07D403/12 , C07D401/14 , C07D491/08 , C07D233/80 , C07D403/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D498/08 , C07D209/48
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。
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公开(公告)号：US09487495B2
公开(公告)日：2016-11-08
申请号：US14369982
申请日：2013-01-07
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D317/46 , C07D317/58 , C07D401/06 , C07D403/06 , C07D407/06 , C07D413/06 , A61K31/495 , A61K31/496 , C07D295/26 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07C271/10 , C07D207/09
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds having the structure: wherein L3, R7, Rd and p are defined herein, which are modulators of MAGL and/or ABHD6. Further provided is the use of these compounds as medicinal agents, processes for their preparation, and pharmaceutical compositions that include the disclosed compounds. The disclosure also provides a method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途，其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。
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公开(公告)号：US11129827B2
公开(公告)日：2021-09-28
申请号：US16431632
申请日：2019-06-04
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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Patent Agency Ranking
公开(公告)号：US09957242B2
公开(公告)日：2018-05-01
申请号：US15272313
申请日：2016-09-21
Applicant: Abide Therapeutics, Inc. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M Lum , Benjamin F. Cravatt
IPC: C07D213/55 , C07D231/12 , C07D261/08 , A61K31/496 , C07D295/205 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D295/26 , C07D307/79 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20150080364A1
公开(公告)日：2015-03-19
申请号：US14383076
申请日：2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Insititute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D487/04 , C07D491/107 , C07D471/04 , C07D405/14 , C07D413/12
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。
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公开(公告)号：US20210386734A1
公开(公告)日：2021-12-16
申请号：US17412102
申请日：2021-08-25
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J.M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61P25/04 , A61K31/506
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US10350205B2
公开(公告)日：2019-07-16
申请号：US15919113
申请日：2018-03-12
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US10093630B2
公开(公告)日：2018-10-09
申请号：US15312998
申请日：2015-05-20
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Dale L. Boger , Katerina Otrubova , Justin S. Cisar , Cheryl A. Grice , Todd K. Jones
IPC: C07D231/14 , C07D491/107 , C07D403/12 , C07D417/12 , C07D405/12 , C07D401/12
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of MAGL, ABHD6, and FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain, solid tumors and/or obesity.
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