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    Flow adapter for drug delivery device
    12.
    发明授权
    Flow adapter for drug delivery device 有权

    公开(公告)号：US11759565B2

    公开(公告)日：2023-09-19

    申请号：US16649412

    申请日：2018-09-26

    Applicant: AMGEN INC.

    Inventor： Carl Conrath ,  Ali Nekouzadeh ,  Basel Hasan Taha

    IPC: A61M5/168 ,  A61M5/142 ,  A61M39/22

    CPC classification number: A61M5/16813 ,  A61M5/14248 ,  A61M39/22 ,  A61M2005/14252

    Abstract: A drug delivery device includes a housing defining a shell, a container, a drive mechanism, a needle assembly having first and second ends, a fluid flow connection, and a flow adapter, each of which is at least partially disposed within the housing. The container has first and second ends and an inner volume to contain a medicament to be administered to a user. The drive mechanism is adapted to exert a force to urge the medicament out the second end of the container. The fluid flow connection is coupled to the second end of the container and the first end of the needle assembly and is adapted to allow the medicament to flow from the container to the needle assembly. The flow adapter includes at least one protrusion for generating a minor head loss to the medicament flowing within the fluid flow connection and helps to reduce variations of injection rates due to variations in drug product viscosities.

    Drug delivery devices with partial drug delivery member retraction
    14.
    发明授权
    Drug delivery devices with partial drug delivery member retraction 有权

    公开(公告)号：US11213620B2

    公开(公告)日：2022-01-04

    申请号：US17278618

    申请日：2019-10-07

    Applicant: AMGEN INC.

    Inventor： Ali Nekouzadeh ,  Carl Conrath ,  Scott Robert Gibson ,  Basel Hasan Taha

    IPC: A61M5/20 ,  A61M5/172 ,  A61M5/145 ,  A61M5/142

    Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.

    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION
    15.
    发明申请
    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION 有权

    公开(公告)号：US20210308376A1

    公开(公告)日：2021-10-07

    申请号：US17278618

    申请日：2019-10-07

    Applicant: AMGEN INC.

    Inventor： Ali Nekouzadeh ,  Carl Conrath ,  Scott Robert Gibson ,  Basel Hasan Taha

    IPC: A61M5/172 ,  A61M5/145 ,  A61M5/142 ,  A61M5/20

    Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.

    DRUG DELIVERY STORAGE DEVICE AND SYSTEM
    16.
    发明申请
    DRUG DELIVERY STORAGE DEVICE AND SYSTEM 审中-公开

    公开(公告)号：US20200289740A1

    公开(公告)日：2020-09-17

    申请号：US15775650

    申请日：2016-12-14

    Applicant: AMGEN INC.

    Inventor： Ferry Tamtoro ,  Huaying Yang ,  Scott Robert Gibson ,  Donald Busby ,  Peter V. Shultz ,  Basel Hasan Taha ,  Adam B. McCullough

    IPC: A61M5/00 ,  A61J7/04 ,  G16H20/17 ,  G16H40/63

    Abstract: A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.

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