公开(公告)号：US20200071405A1

公开(公告)日：2020-03-05

申请号：US16570129

申请日：2019-09-13

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbüse ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/60 ,  C07K16/46

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

公开(公告)号：US20190016805A1

公开(公告)日：2019-01-17

申请号：US16040927

申请日：2018-07-20

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbüse ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28 ,  A61K47/60 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

公开(公告)号：US20180208654A1

公开(公告)日：2018-07-26

申请号：US15878047

申请日：2018-01-23

Applicant: AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

公开(公告)号：US20180002450A1

公开(公告)日：2018-01-04

申请号：US15673539

申请日：2017-08-10

Applicant: AMGEN INC. ,  AMGEN RESEARCH (MUNICH) GMBH

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  Peter Kufer ,  Patrick Hoffmann ,  Tobias Raum ,  Ralf Lutterbüse ,  Elisabeth Nahrwold ,  Claudia Blumel

IPC: C07K16/46 ,  C07K16/30 ,  A61K47/60 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00

Abstract: The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

公开(公告)号：US20160032019A1

公开(公告)日：2016-02-04

申请号：US14815861

申请日：2015-07-31

Applicant: AMGEN INC. ,  AMGEN RESEARCH (MUNICH) GMBH

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  Peter Kufer ,  Patrick Hoffmann ,  Tobias Raum ,  Ralf Lutterbüse ,  Elisabeth Nahrwold ,  Claudia Blumel

IPC: C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00

Abstract: The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract translation: 本发明提供了双特异性抗体构建体，其包含与靶细胞表面上的人CDH19结合的第一人结合结构域和与T细胞表面上的人CD3结合的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。

公开(公告)号：US20150368343A1

公开(公告)日：2015-12-24

申请号：US14761839

申请日：2014-01-27

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbuese ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2896 ,  C07K16/3053 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract translation: 本发明提供了一种抗体构建物，其包含能够结合靶细胞表面上的人CDH19的第一人结合结构域和能够结合T细胞表面上的人CD3的第二结构域。 此外，本发明涉及编码抗体构建体的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明涉及制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。