公开(公告)号：US09915668B2

公开(公告)日：2018-03-13

申请号：US15479110

申请日：2017-04-04

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael Sierks ,  Huilai Tian

IPC: G01N33/68 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/005 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/76 ,  C12N15/1037 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/7047

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US09650436B2

公开(公告)日：2017-05-16

申请号：US14434742

申请日：2013-10-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael Sierks ,  Huilai Tian

IPC: C07K16/18 ,  G01N33/68 ,  C07K16/00 ,  C12N15/10 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/005 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/76 ,  C12N15/1037 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/7047

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau.

公开(公告)号：US11300576B2

公开(公告)日：2022-04-12

申请号：US16776218

申请日：2020-01-29

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael Sierks ,  Stephanie Williams

IPC: G01N33/68 ,  C07K14/47

Abstract: Disclosed are diagnostics for neurodegenerative diseases, and in particular to design ankyrin repeat protein (DARPins) reagents that distinguish Alzheimer's disease (AD) from Parkinson's disease (PD). Methods of diagnosing, monitoring treatment efficacy and developing treatments for neurodegenerative diseases, such as AD and PD are disclosed based upon the use of the AD or PD specific DARPins.

公开(公告)号：US20180364577A1

公开(公告)日：2018-12-20

申请号：US16106699

申请日：2018-08-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Michael Sierks ,  Stephanie Williams

IPC: G03F7/20 ,  C07K14/47

Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject.