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公开(公告)号：US12084490B2
公开(公告)日：2024-09-10
申请号：US17327462
申请日：2021-05-21
Inventor： Michael Sierks , Huilai Tian
CPC classification number: C07K16/18 , C07K16/005 , C12N15/1037 , G01N33/6896 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/62 , C07K2317/622 , C07K2317/76 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/7047
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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公开(公告)号：US20200241014A1
公开(公告)日：2020-07-30
申请号：US16776218
申请日：2020-01-29
Inventor： Michael Sierks , Stephanie Williams
Abstract: Disclosed are diagnostics for neurodegenerative diseases, and in particular to design ankyrin repeat protein (DARPins) reagents that distinguish Alzheimer's disease (AD) from Parkinson's disease (PD). Methods of diagnosing, monitoring treatment efficacy and developing treatments for neurodegenerative diseases, such as AD and PD are disclosed based upon the use of the AD or PD specific DARPins.
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公开(公告)号：US10191068B2
公开(公告)日：2019-01-29
申请号：US15114356
申请日：2015-02-02
Inventor： Michael Sierks , Stephanie Williams , Lalitha Venkataraman
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
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公开(公告)号：US20160291037A1
公开(公告)日：2016-10-06
申请号：US15087682
申请日：2016-03-31
Inventor： Michael Sierks , Stephanie Williams
CPC classification number: G03F7/2004 , C07K14/47 , G03F7/201 , G03F7/2022
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject.
Abstract translation: 本发明提供用于确定创伤性脑损伤（TBI）风险的检测试剂和方法，对受试者的神经元损伤量和/或对神经变性疾病易感性的评估。
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公开(公告)号：US11549113B2
公开(公告)日：2023-01-10
申请号：US16712652
申请日：2019-12-12
Inventor： Michael Sierks , Lalitha Venkataraman , Wei Xin
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
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Patent Agency Ranking
公开(公告)号：US11175584B2
公开(公告)日：2021-11-16
申请号：US16106699
申请日：2018-08-21
Inventor： Michael Sierks , Stephanie Williams
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject.
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公开(公告)号：US20220276264A1
公开(公告)日：2022-09-01
申请号：US17687587
申请日：2022-03-04
Inventor： Michael Sierks , Stephanie Williams
Abstract: Disclosed are diagnostics kits and compositions for neurodegenerative diseases, and in particular to design ankyrin repeat protein (DARPins) reagents that distinguish Alzheimer's disease (AD) from Parkinson's disease (PD). Methods of diagnosing, monitoring treatment efficacy and developing treatments for neurodegenerative diseases, such as AD and PD are disclosed based upon the use of the AD or PD specific DARPins.
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公开(公告)号：US11046755B2
公开(公告)日：2021-06-29
申请号：US16672034
申请日：2019-11-01
Inventor： Michael Sierks , Huilai Tian
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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公开(公告)号：US11022618B2
公开(公告)日：2021-06-01
申请号：US16211006
申请日：2018-12-05
Inventor： Michael Sierks , Stephanie Williams , Lalitha Venkataraman
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
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公开(公告)号：US09938330B2
公开(公告)日：2018-04-10
申请号：US14388209
申请日：2013-03-12
Inventor： Michael Sierks , Mark Hayes
IPC: G01N27/447 , C07K14/47 , B03C5/00 , B03C5/02 , B01L3/00
CPC classification number: C07K14/4711 , B01L3/5027 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N27/447
Abstract: The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material.
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