中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.02 seconds)

    Systems and methods for assessing data collected from an electrically active cell culture
    12.
    发明授权
    Systems and methods for assessing data collected from an electrically active cell culture 有权

    公开(公告)号：US10969382B2

    公开(公告)日：2021-04-06

    申请号：US15964139

    申请日：2018-04-27

    Applicant: Axion BioSystems, Inc.

    Inventor： Stacie Ann Chvatal ,  Daniel Christopher Millard ,  James David Ross

    IPC: G01N30/50 ,  G01N33/50 ,  H04L29/08 ,  A61B5/04 ,  A61B5/0464

    Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.

    DEVICE AND SYSTEM FOR CREATING AND MAINTAINING A LOCALIZED ENVIRONMENT FOR A CELL CULTURE PLATE
    15.
    发明申请
    DEVICE AND SYSTEM FOR CREATING AND MAINTAINING A LOCALIZED ENVIRONMENT FOR A CELL CULTURE PLATE 审中-公开
    用于创建和维护细胞培养板的本地化环境的装置和系统

    公开(公告)号：US20170058246A1

    公开(公告)日：2017-03-02

    申请号：US14838575

    申请日：2015-08-28

    Applicant: Axion BioSystems, Inc.

    Inventor： Robert Dixon Grier, JR. ,  David Ernest Irvine ,  James David Ross

    IPC: C12M1/12 ,  C12M3/00 ,  C12M1/34 ,  C12M1/00

    CPC classification number: C12M41/34 ,  C12M23/04 ,  C12M23/12 ,  C12M23/40 ,  C12M23/42 ,  C12M23/44 ,  C12M41/14

    Abstract: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.

    Abstract translation: 提供了用于促进细胞和材料在配置用于高通量应用的培养板中的放置的装置，系统和方法。 培养系统具有培养板，该培养板具有用于引导将细胞和材料放置在培养板的各个培养孔中的盖子。 盖子可以提供与包括生物传感器板和生物培养板的电生理学培养板的耦合，其中生物传感器板位于培养皿板下并且连接到培养皿板，使得每个生物传感器可操作地偶联到多个培养物的一个培养物 井。 本文还提供了物理地影响接收在培养板中的流体定位的容纳装置。

Patent Agency Ranking