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11.发明申请公开(公告)号：US20140066621A1
公开(公告)日：2014-03-06
申请号：US13952278
申请日：2013-07-26
Inventor： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiahong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Peter Edward Czabotar , Guillaume Laurent Lessene , Peter Malcolm Colman , William J. McClellan
IPC: C07D401/12 , C07D211/58 , C07D309/08
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20140051683A1
公开(公告)日：2014-02-20
申请号：US13868951
申请日：2013-04-23
Applicant: AbbVie Inc.
Inventor： Xilu WANG , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D209/42 , C07D401/12 , C07D401/04 , C07D413/12
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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13.发明公开公开(公告)号：US20240043404A1
公开(公告)日：2024-02-08
申请号：US18462355
申请日：2023-09-06
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
CPC classification number: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496 , Y02A50/30
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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14.发明申请公开(公告)号：US20200246460A1
公开(公告)日：2020-08-06
申请号：US16563507
申请日：2019-09-06
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC: A61K45/06 , A61K31/4725 , A61K31/4985 , A61K31/498 , A61K47/68 , A61K31/538 , A61K31/4709 , C07D417/14 , C07D487/04 , C07D513/04
Abstract: The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
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15.发明申请公开(公告)号：US20190142941A1
公开(公告)日：2019-05-16
申请号：US16240544
申请日：2019-01-04
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC: A61K45/06 , A61K47/68 , C07D513/04 , C07D487/04 , A61K31/538 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , C07D417/14
Abstract: The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
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Patent Agency Ranking
16.发明申请BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same 审中-公开具有低细胞渗透性的BCL-XL抑制性化合物和包括其的抗体药物偶联物公开(公告)号：US20160339117A1
公开(公告)日：2016-11-24
申请号：US14963506
申请日：2015-12-09
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC: A61K47/48 , C07D417/14 , A61K31/4725 , C07D487/04 , A61K31/538 , A61K31/498 , A61K31/4709 , A61K31/4985 , A61K45/06 , C07D513/04
CPC classification number: A61K45/06 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/538 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K47/6889 , C07D417/14 , C07D487/04 , C07D513/04
Abstract: The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
Abstract translation: 本公开涉及具有低细胞通透性的Bcl-xL抑制剂，包含抑制剂的抗体药物偶联物（ADC），可用于合成ADC的合成物，包含抑制剂或ADC的组合物，以及使用抑制剂和ADC的各种方法。
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17.发明授权Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases 有权凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号：US09493431B2
公开(公告)日：2016-11-15
申请号：US14855176
申请日：2015-09-15
Applicant: AbbVie Inc.
Inventor： Aaron R. Kunzer , Steven W. Elmore , Gerard M. Sullivan
IPC: C07D277/36 , A61K31/426 , A61K31/427 , C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04 , C07D333/42
CPC classification number: C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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18.发明申请APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的疫苗诱导剂公开(公告)号：US20150329541A1
公开(公告)日：2015-11-19
申请号：US14694965
申请日：2015-04-23
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D471/04
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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19.发明授权公开(公告)号：US09174982B2
公开(公告)日：2015-11-03
申请号：US14038304
申请日：2013-09-26
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: C07D209/82 , C07D403/12 , C07D401/14 , C07D471/04 , C07D519/00 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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20.发明授权Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases 有权Bcl-2选择性细胞凋亡诱导剂用于治疗癌症和免疫疾病公开(公告)号：US09125913B2
公开(公告)日：2015-09-08
申请号：US14058159
申请日：2013-10-18
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D471/04 , A61K31/407 , A61K45/06 , C07D241/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D487/04
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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