公开(公告)号：US20150072978A1

公开(公告)日：2015-03-12

申请号：US14543817

申请日：2014-11-17

Applicant: AbbVie Inc.

Inventor： Le Wang ,  George Doherty ,  Xilu Wang ,  Zhi-Fu Tao ,  Milan Bruncko ,  Aaron R. Kunzer ,  Michael D. Wendt ,  Xiaohong Song ,  Robin Frey ,  Todd M. Hansen ,  Gerard M. Sullivan ,  Andrew Judd ,  Andrew J. Souers

IPC: C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D493/08 ,  C07D513/04

CPC classification number: A61K31/4725 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07D513/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.

Abstract translation: 公开了抑制抗凋亡Bcl-xL蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-xL蛋白。

公开(公告)号：US08969375B2

公开(公告)日：2015-03-03

申请号：US14207841

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Chunqiu Lai ,  Zhi-Fu Tao ,  Keith W. Woods ,  Thomas D. Penning ,  Andrew J. Souers ,  Anthony Mastracchio ,  Julie M. Miyashiro ,  Yunsong Tong

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Disclosed are compound of Formula (Ia), wherein R1A, R1, R2, R10, J, L, T, X, Y, and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

Abstract translation: 公开了式（Ia）的化合物，其中R 1A，R 1，R 2，R 10，J，L，T，X，Y和Z如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（Ia）化合物的药物组合物。

公开(公告)号：US20140088106A1

公开(公告)日：2014-03-27

申请号：US14053544

申请日：2013-10-14

Applicant: AbbVie Inc.

Inventor： Milan Bruncko ,  Yujia Dai ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  William J. McClellan ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Todd M. Hansen

IPC: C07D213/76 ,  A61K31/495 ,  A61K31/496 ,  C07D309/32 ,  C07D211/06 ,  C07D295/14 ,  C07D405/12 ,  C07D417/12 ,  A61K45/06 ,  C07D405/14 ,  A61K31/5377 ,  C07D403/12

CPC classification number: C07D213/76 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D211/06 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/14 ,  C07D295/30 ,  C07D309/04 ,  C07D309/32 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：US20140066621A1

公开(公告)日：2014-03-06

申请号：US13952278

申请日：2013-07-26

Applicant: The Walter and Eliza Hall Institute of Medical Research ,  AbbVie Inc.

Inventor： Milan Bruncko ,  Yujia Dai ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Robert A. Mantei ,  Chang H. Park ,  Cheol-Min Park ,  Andrew M. Petros ,  Xiahong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Peter Edward Czabotar ,  Guillaume Laurent Lessene ,  Peter Malcolm Colman ,  William J. McClellan

IPC: C07D401/12 ,  C07D211/58 ,  C07D309/08

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20140051683A1

公开(公告)日：2014-02-20

申请号：US13868951

申请日：2013-04-23

Applicant: AbbVie Inc.

Inventor： Xilu WANG ,  Xiaohong Song ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Lisa A. Hasvold ,  Le Wang ,  Zhi-Fu Tao ,  Aaron R. Kunzer

IPC: C07D209/42 ,  C07D401/12 ,  C07D401/04 ,  C07D413/12

CPC classification number: C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

公开(公告)号：US20240058450A1

公开(公告)日：2024-02-22

申请号：US17804696

申请日：2022-05-31

Applicant: AbbVie Inc.

Inventor： Scott L. Ackler ,  Nathan B. Bennett ,  Erwin R. Boghaert ,  Steve C. Cullen ,  George Doherty ,  Robin R. Frey ,  Anthony R. Haight ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Violeta L. Marin ,  Xiaoqiang Shen ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Xilu Wang ,  Dennie S. Welch ,  Michael D. Wendt

IPC: A61K45/06 ,  C07D417/14 ,  C07D513/04 ,  A61K47/68 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/538 ,  C07D487/04

CPC classification number: A61K45/06 ,  C07D417/14 ,  C07D513/04 ,  A61K47/6889 ,  A61K47/6803 ,  A61K47/6849 ,  C07D487/04 ,  A61K47/6883 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/538 ,  A61K47/6851

Abstract: The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.

公开(公告)号：US20230183261A1

公开(公告)日：2023-06-15

申请号：US17649906

申请日：2022-02-03

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Anthony Mastracchio ,  Xilu Wang ,  Cheng Ji ,  Michael D. Wendt ,  Xiaohong Song ,  George A. Doherty ,  Katja Jantos ,  Wilfried Braje ,  Andreas Kling ,  Frauke Pohlki ,  Thomas D. Penning

IPC: C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00 ,  A61P35/02

Abstract: The present disclosure provides for compounds of formula (I)




wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20210171637A1

公开(公告)日：2021-06-10

申请号：US16819036

申请日：2020-03-13

Applicant: AbbVie Inc.

Inventor： Lorenzo Benatuil ,  Debra Chao ,  Kamel Izeradjene ,  Andrew S. Judd ,  Andrew C. Phillips ,  Andrew J. Souers ,  Archana Thakur ,  Milan Bruncko

IPC: C07K16/28 ,  A61K47/68 ,  A61K31/498 ,  A61K31/437 ,  A61K31/519

Abstract: The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

公开(公告)号：US10676485B2

公开(公告)日：2020-06-09

申请号：US15998789

申请日：2018-08-15

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Andrew J. Souers ,  Zhi-Fu Tao ,  Anthony Mastracchio ,  Xilu Wang ,  Cheng Ji ,  Michael D. Wendt ,  Xiaohong Song ,  George A. Doherty ,  Thomas D. Penning

IPC: A61K31/395 ,  A61P35/02 ,  C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00

Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20200002421A1

公开(公告)日：2020-01-02

申请号：US16308622

申请日：2017-06-07

Applicant: AbbVie Inc.

Inventor： Lorenzo Benatuil ,  Milan Bruncko ,  Debra Chao ,  Kamel Izeradjene ,  Andrew S. Judd ,  Andrew C. Phillips ,  Andrew J. Souers ,  Archana Thakur ,  George Doherty ,  Robin R. Frey ,  Xiaohong Song ,  Gerard M. Sullivan ,  Zhi-Fu Tao

IPC: C07K16/28 ,  A61K47/68 ,  C07H15/26 ,  A61P35/00

Abstract: The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.