公开(公告)号：US09803009B2

公开(公告)日：2017-10-31

申请号：US13659658

申请日：2012-10-24

Applicant: AbbVie Inc.

Inventor： Chung-Ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John Memmott ,  Jennifer Perez ,  Suju Zhong ,  Carrie Goodreau ,  Anca Clabbers

IPC: A61K39/395 ,  A61K39/00 ,  C12P21/08 ,  C07K16/00 ,  C07K16/24 ,  C07K16/46 ,  G01N33/68 ,  A61K47/48 ,  A61K45/06

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6847 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863

Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US09655964B2

公开(公告)日：2017-05-23

申请号：US13659666

申请日：2012-10-24

Applicant: AbbVie Inc.

Inventor： Jennifer Perez ,  Suju Zhong ,  Lucia Eaton ,  Anca Clabbers ,  Chung-Ming Hsieh ,  Lorenzo Benatuil ,  Yuliya Kutskova ,  John E. Memmott ,  Margaret Hugunin ,  Alyssa Brito

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/46 ,  A61K45/06 ,  G01N33/53 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5308

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：US09493568B2

公开(公告)日：2016-11-15

申请号：US14664453

申请日：2015-03-20

Applicant: AbbVie Inc.

Inventor： Edward B. Reilly ,  Andrew C. Phillips ,  Lorenzo Benatuil ,  Chung-Ming Hsieh ,  Jennifer Perez

IPC: C07K16/28 ,  A61K47/48 ,  C07K14/00 ,  A61K39/00

CPC classification number: A61K47/6811 ,  A61K47/6803 ,  A61K47/6847 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6863 ,  A61K47/6865 ,  A61K47/6889 ,  A61K2039/505 ,  C07K14/00 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Abstract translation: 本发明涉及抗表皮生长因子（EGFR）抗体和抗体药物偶联物（ADC），包括使用所述抗体和ADC的组合物和方法。