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公开(公告)号：US09803009B2
公开(公告)日：2017-10-31
申请号：US13659658
申请日：2012-10-24
Applicant: AbbVie Inc.
Inventor： Chung-Ming Hsieh , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
IPC: A61K39/395 , A61K39/00 , C12P21/08 , C07K16/00 , C07K16/24 , C07K16/46 , G01N33/68 , A61K47/48 , A61K45/06
CPC classification number: C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/6847 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6863
Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20150266977A1
公开(公告)日：2015-09-24
申请号：US14625575
申请日：2015-02-18
Applicant: AbbVie Inc.
Inventor： Chung-Ming Hsieh , Alexander Ivanov , Wendy Waegell , Yulia Kutskova , John Memmott , Lorenzo Benatuil , Jacqueline Bixby , Emma Fung , Sahana Bose , Alyssa Brito
CPC classification number: C07K16/468 , A61K31/353 , A61K31/439 , A61K31/44 , A61K31/4439 , A61K31/519 , A61K31/56 , A61K38/13 , A61K38/1793 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/19 , A61K38/191 , A61K38/2026 , A61K38/2066 , A61K38/2073 , A61K38/217 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/60 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
Abstract translation: 与用于治疗，预防和诊断硬化性相关疾病的组合物和方法一起描述了结合硬化蛋白或硬化性骨肉瘤和TNF的蛋白质，并用于检测细胞，组织，样品和组合物中的硬化蛋白或硬化性骨肉瘤和TNF。
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公开(公告)号：US20210238270A1
公开(公告)日：2021-08-05
申请号：US17024459
申请日：2020-09-17
Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
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4.发明申请公开(公告)号：US20160326240A1
公开(公告)日：2016-11-10
申请号：US15155815
申请日：2016-05-16
Applicant: ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
CPC classification number: C07K16/22 , A61K39/3955 , A61K49/0002 , A61K49/0058 , A61K51/1018 , A61K51/1021 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/18 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , G01N33/6896 , G01N2333/705 , G01N2800/28 , G01N2800/285
Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
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公开(公告)号：US09365643B2
公开(公告)日：2016-06-14
申请号：US14580818
申请日：2014-12-23
Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
CPC classification number: C07K16/22 , A61K39/3955 , A61K49/0002 , A61K49/0058 , A61K51/1018 , A61K51/1021 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/18 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , G01N33/6896 , G01N2333/705 , G01N2800/28 , G01N2800/285
Abstract: Provided herein are antibodies that bind to Repulsive Guidance Molecule a (RGMa) and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
Abstract translation: 本文提供了结合排斥导向分子a（RGMa）的抗体以及使用抗体治疗和诊断神经突变性疾病和病症的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190276526A1
公开(公告)日：2019-09-12
申请号：US16166702
申请日：2018-10-22
Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
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7.发明申请COMPOSITION AND METHOD FOR THE DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH NEURITE DEGENERATION 有权诊断和治疗与神经衰弱相关的疾病的组合物和方法公开(公告)号：US20150118156A1
公开(公告)日：2015-04-30
申请号：US14580818
申请日：2014-12-23
Applicant: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
IPC: C07K16/22 , G01N33/68 , A61K51/10 , A61K39/395 , A61K49/00
CPC classification number: C07K16/22 , A61K39/3955 , A61K49/0002 , A61K49/0058 , A61K51/1018 , A61K51/1021 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/18 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , G01N33/6896 , G01N2333/705 , G01N2800/28 , G01N2800/285
Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
Abstract translation: 本文提供了使用抗体治疗和诊断神经突变性疾病和病症的抗体和方法。
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公开(公告)号：US20140079705A1
公开(公告)日：2014-03-20
申请号：US14082502
申请日：2013-11-18
Applicant: Abbvie Inc.
Inventor： Chung-ming Hsieh , Jennifer Perez , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Suju Zhong , Lucia Eaton , Margaret Hugunin , Alyssa Brito , Anca Clabbers
CPC classification number: A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/241 , C07K16/244 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/5308
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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9.发明申请COMPOSITION AND METHOD FOR THE DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH NEURITE DEGENERATION 审中-公开诊断和治疗与神经衰弱相关的疾病的组合物和方法公开(公告)号：US20140023659A1
公开(公告)日：2014-01-23
申请号：US14033707
申请日：2013-09-23
Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K39/3955 , A61K49/0002 , A61K49/0058 , A61K51/1018 , A61K51/1021 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/18 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/76 , G01N33/6896 , G01N2333/705 , G01N2800/28 , G01N2800/285
Abstract: Provided herein are antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
Abstract translation: 本文提供了使用抗体治疗和诊断神经突变性疾病和病症的抗体和方法。
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公开(公告)号：US10106602B2
公开(公告)日：2018-10-23
申请号：US15155815
申请日：2016-05-16
Applicant: ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
Inventor： Bernhard Mueller , Lili Huang , Philip D. Bardwell , Yuliya Kutskova , John Memmott
IPC: A61K39/35 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/28 , A61K39/395 , A61K49/00 , A61K51/10 , G01N33/68 , C07B59/00 , A61K39/00
Abstract: Provided herein are anti-Repulsive Guidance Molecule a (RGMa) antibodies and methods of using the antibodies to treat and diagnose neurite degenerative diseases and disorders.
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