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11.发明申请公开(公告)号：US20150152097A1
公开(公告)日：2015-06-04
申请号：US14559828
申请日：2014-12-03
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: C07D417/14
CPC classification number: A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US09035047B2
公开(公告)日：2015-05-19
申请号：US13868951
申请日：2013-04-23
Applicant: AbbVie Inc.
Inventor： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D413/14 , A61K31/5377 , C07D209/42 , C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , C07D401/04 , C07D413/12
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
Abstract translation: 公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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13.发明授权公开(公告)号：US08952157B2
公开(公告)日：2015-02-10
申请号：US13952278
申请日：2013-07-26
Inventor： Hong Ding , George A. Doherty , Steven W. Elmore , Laura Hexamer , Aaron R. Kunzer , Cheol-Min Park , Xiahong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Le Wang , Michael D. Wendt , Peter Edward Czabotar , Guillaume Laurent Lessene , Peter Malcolm Colman
IPC: C07D241/12 , C07D401/10 , C07D401/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D309/08
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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14.发明授权公开(公告)号：US08889675B2
公开(公告)日：2014-11-18
申请号：US13649900
申请日：2012-10-11
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/54 , C07D401/04 , C07D417/14 , C07D471/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20230101559A1
公开(公告)日：2023-03-30
申请号：US17654547
申请日：2022-03-11
Applicant: AbbVie Inc.
Inventor： Andrew Bogdan , Steven Fidanze , Keith McDaniel , John Pratt , Le Wang
IPC: C07D401/12 , C07D213/64 , C07D401/04
Abstract: The present invention provides for compounds of formula (I) wherein R1, Y, X1, X2, R2, R3, R4, R5, R6, and m have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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Patent Agency Ranking
公开(公告)号：US20210236508A1
公开(公告)日：2021-08-05
申请号：US16996090
申请日：2020-08-18
Applicant: AbbVie Inc.
Inventor： Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC: A61K31/541 , C07D487/04 , C07D471/04 , A61K31/437 , A61K31/5025 , A61K31/5377 , A61K45/06
Abstract: The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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17.发明申请公开(公告)号：US20210221789A1
公开(公告)日：2021-07-22
申请号：US17004841
申请日：2020-08-27
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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18.发明申请公开(公告)号：US20200253954A1
公开(公告)日：2020-08-13
申请号：US16578229
申请日：2019-09-20
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D513/04 , C07D493/08 , C07D487/04 , C07D471/04 , C07D417/14 , C07D401/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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19.发明申请公开(公告)号：US20200231566A1
公开(公告)日：2020-07-23
申请号：US16557819
申请日：2019-08-30
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , A61K31/496 , C07D403/12 , C07D209/82 , C07D471/04 , C07D519/00 , C07D401/14
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US10131657B2
公开(公告)日：2018-11-20
申请号：US14392200
申请日：2014-05-13
Applicant: AbbVie Inc.
Inventor： Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James Holms , Dachun Liu , William McClellan , Keith McDaniel , Jasmina Marjanovic , George Sheppard , Le Wang
IPC: A61K31/437 , A61K31/454 , A61K31/4545 , C07D471/04 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/497 , A61K31/506
Abstract: The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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