-
1.发明申请公开(公告)号：US20200331907A1
公开(公告)日：2020-10-22
申请号：US16707777
申请日：2019-12-09
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496 , A61K45/06 , A61P37/00 , A61P35/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bc1-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
-
2.发明申请公开(公告)号：US20200253954A1
公开(公告)日：2020-08-13
申请号：US16578229
申请日：2019-09-20
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC分类号： A61K31/4725 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D513/04 , C07D493/08 , C07D487/04 , C07D471/04 , C07D417/14 , C07D401/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
-
公开(公告)号：US09872861B2
公开(公告)日：2018-01-23
申请号：US15136582
申请日：2016-04-22
申请人： AbbVie Inc.
发明人： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/5377 , A61K31/496
摘要： This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.
-
![Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors](/abs-image/US/2017/10/24/US09796708B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796708B2
公开(公告)日：2017-10-24
申请号：US14780018
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iguturi , Madhu Babu Dabbeeru
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
-
5.发明授权Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 有权凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号：US08940737B2
公开(公告)日：2015-01-27
申请号：US13649950
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC分类号： A61K31/54 , A61K45/06 , C07D417/14 , A61K31/5377 , A61K31/4725
CPC分类号： A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
摘要翻译： 公开了抑制抗凋亡Bcl-xL蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-xL蛋白。
-
6.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20130096121A1
公开(公告)日：2013-04-18
申请号：US13649950
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC分类号： A61K31/4725 , A61K31/5377 , A61P35/02 , C07D417/14 , A61P35/00
CPC分类号： A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bc1-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bc1-xL protein.
摘要翻译： 公开了抑制抗凋亡Bc1-xL蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达有抗凋亡Bc1-xL蛋白。
-
公开(公告)号：US20220259226A1
公开(公告)日：2022-08-18
申请号：US17660355
申请日：2022-04-22
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Yujia Dai , Jane Gong , Roberto Risi , Yiyun Yu , Guidong Zhu
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
-
公开(公告)号：US20200222413A1
公开(公告)日：2020-07-16
申请号：US16415515
申请日：2019-05-17
申请人： AbbVie Inc.
发明人： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC分类号： A61K31/5377 , A61K31/496
摘要： This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.
-
公开(公告)号：US20180369250A1
公开(公告)日：2018-12-27
申请号：US15838605
申请日：2017-12-12
申请人： AbbVie Inc.
发明人： Steven Elmore , Andrew Souers , Lichun Wang , Tariq Ghayur , Stuart J. Perper
IPC分类号： A61K31/5377 , A61K31/496
摘要： This invention pertains to methods of treating systemic lupus erythematosus and Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-XL.
-
公开(公告)号：US09877958B2
公开(公告)日：2018-01-30
申请号：US14994824
申请日：2016-01-13
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC分类号： A61K31/535 , A61K31/4725 , A61K31/5377 , C07D417/14 , A61K45/06 , C07D471/04
CPC分类号： A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.078 秒)
