公开(公告)号：US10105365B2

公开(公告)日：2018-10-23

申请号：US15639424

申请日：2017-06-30

Applicant: AbbVie Inc.

Inventor： Jonathan M. Miller ,  John B. Morris ,  Nancy E. Sever ,  Eric A. Schmitt ,  Ping X. Gao ,  Yi Shi ,  Yi Gao ,  Bernd Liepold ,  Anna Moosmann ,  Mirko Pauli ,  Fatih Durak ,  Thomas Kessler ,  Peter Hoelig ,  Karin Rosenblatt ,  Drazen Kostelac ,  Rajeev Gokhale ,  Mark Costello ,  Carl Knable ,  Susan George

IPC: A61K31/513 ,  A61K47/38 ,  A61K9/24 ,  A61K31/427 ,  A61K31/497 ,  A61K47/32 ,  A61K31/4025

Abstract: The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

公开(公告)号：US20160375087A1

公开(公告)日：2016-12-29

申请号：US15192211

申请日：2016-06-24

Applicant: AbbVie Inc.

Inventor： Nancy E. Sever ,  Ulrich Westedt ,  Ute Lander ,  Katrin Schneider ,  Benedikt Steitz ,  Thomas Mueller ,  Regina Reul ,  Constanze Obermiller ,  Adivaraha Jayasankar ,  Michael Simon ,  Yi Gao ,  Harald Hach ,  Samuel Kyeremateng ,  Katharina Asmus ,  Ping Tong ,  Donghua Zhu ,  Marius Naris ,  Colleen Garrett

IPC: A61K38/06 ,  A61K9/28 ,  A61K9/20 ,  A61K9/16 ,  A61K31/4184 ,  A61K9/24

CPC classification number: A61K38/06 ,  A61K9/146 ,  A61K9/1688 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2866 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/498 ,  A61K2300/00

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

公开(公告)号：US09333204B2

公开(公告)日：2016-05-10

申请号：US14677611

申请日：2015-04-02

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Jonathan M. Miller ,  John B. Morris ,  Nancy E. Sever ,  Eric A. Schmitt ,  Ping X. Gao ,  Yi Shi ,  Yi Gao ,  Bernd Liepold ,  Anna Moosmann ,  Mirko Pauli ,  Fatih Durak ,  Thomas Kessler ,  Peter A. Hoelig ,  Karin Rosenblatt ,  Drazen Kostelac ,  Rajeev Gokhale ,  Mark Costello ,  Carl Knable

IPC: A61K31/4965 ,  A01N43/54 ,  A01N43/36 ,  A61K31/513 ,  A61K47/32 ,  A61K47/38 ,  A61K9/24 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/497

CPC classification number: A61K31/513 ,  A61K9/209 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/497 ,  A61K47/32 ,  A61K47/38 ,  A61K2300/00

Abstract: The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

Abstract translation: 本公开涉及包含抗病毒化合物的固体剂型和使用这些剂型来治疗抗病毒感染的方法。