公开(公告)号：US20190040136A1

公开(公告)日：2019-02-07

申请号：US16079947

申请日：2017-03-03

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-I WANG ,  Hsueh Ling Janice OH ,  Siok Ping YEO ,  Chia Yin LEE

IPC: C07K16/28 ,  C12N15/62 ,  A61P35/00 ,  A61P31/00

Abstract: Anti-LAG-3 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US20180208663A1

公开(公告)日：2018-07-26

申请号：US15922921

申请日：2018-03-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I WANG ,  Peter BRAUER ,  Siok Ping YEO ,  Hwee Ching TAN ,  John Edward CONNOLLY

IPC: C07K16/28 ,  A61K47/68

CPC classification number: C07K16/2866 ,  A61K38/1709 ,  A61K39/3955 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/1036 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US20180072798A1

公开(公告)日：2018-03-15

申请号：US15558937

申请日：2016-03-17

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  National University of Singapore

Inventor： Cheng-I WANG ,  Katja FINK ,  Paul MACARY ,  Roland ZUEST ,  Meihui XU

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/1081 ,  A61K2039/505 ,  A61P31/12 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/185 ,  Y02A50/386 ,  Y02A50/53

Abstract: Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.