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公开(公告)号:US10919962B2
公开(公告)日:2021-02-16
申请号:US16192537
申请日:2018-11-15
Applicant: Agency for Science, Technology and Research
Inventor: Cheng-I Wang , Angeline Goh , Siok Ping Yeo , Alessandra Rosa Mortellaro , Subhra Kumar Biswas , Florent Ginhoux , Pingyu Zhong
IPC: A61K39/395 , C07K16/24 , A61K39/00
Abstract: The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.
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公开(公告)号:US10472423B2
公开(公告)日:2019-11-12
申请号:US15908218
申请日:2018-02-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Cheng-I Wang , Peter Brauer , Siok Ping Yeo , Hwee Ching Tan , John Edward Connolly
IPC: A61K39/395 , C07K16/28 , C07K16/24 , A61P35/00 , C12N5/0783 , A61K38/20 , A61K39/00
Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
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公开(公告)号:US20190185564A1
公开(公告)日:2019-06-20
申请号:US16294474
申请日:2019-03-06
Applicant: Agency for Science, Technology and Research
Inventor: Cheng-I Wang , Hsueh Ling Janice Oh , Siok Ping Yeo , Yun Pei Sharon Goh
CPC classification number: C07K16/2803 , C07K16/2809 , C07K16/3061 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/92
Abstract: Anti-TIM-3 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
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公开(公告)号:US20170226211A1
公开(公告)日:2017-08-10
申请号:US15486468
申请日:2017-04-13
Applicant: Agency for Science, Technology and Research
Inventor: Cheng-I Wang , Eve Ngoh , Siok Ping Yeo
CPC classification number: C07K16/2818 , A61K9/0019 , A61K2039/505 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: Anti-CTLA-4 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.
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公开(公告)号:US20240052046A1
公开(公告)日:2024-02-15
申请号:US18344711
申请日:2023-06-29
Inventor: Peter Brauer , John Edward Connolly , Richard Hopkins , Junyun Lai , Jianrong Lionel Low , Kar Wai Tan , Cheng-I Wang , Siok Ping Yeo
CPC classification number: C07K16/2866 , A61P35/00 , C07K16/468 , C07K2317/565 , C07K2317/75
Abstract: Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.
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公开(公告)号:US11267887B2
公开(公告)日:2022-03-08
申请号:US16099652
申请日:2017-04-13
Applicant: Agency For Science, Technology and Research
Inventor: Cheng-I Wang , Eve Ngoh , Siok Ping Yeo
IPC: A61K39/395 , A61K39/00 , C07K16/42 , C07K16/46 , C07K16/28 , A61K9/00 , A61P31/00 , A61P35/00 , A61K35/17 , C12N5/0783 , C12N15/85 , G01N33/574
Abstract: Anti-CTLA-4 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.
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公开(公告)号:US10696747B2
公开(公告)日:2020-06-30
申请号:US16112008
申请日:2018-08-24
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Cheng-I Wang , Peter Brauer , Siok Ping Yeo , Hwee Ching Tan , John Edward Connolly
Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
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公开(公告)号:US10316078B2
公开(公告)日:2019-06-11
申请号:US15558937
申请日:2016-03-17
Inventor: Cheng-I Wang , Katja Fink , Paul Macary , Roland Zuest , Meihui Xu
IPC: C07K16/10 , G01N33/569 , A61P31/12 , A61K39/00
Abstract: Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.
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公开(公告)号:US10259874B2
公开(公告)日:2019-04-16
申请号:US15521685
申请日:2015-10-27
Applicant: Agency for Science, Technology and Research
Inventor: Cheng-I Wang , Hsueh Ling Janice Oh , Siok Ping Yeo , Yun Pei Sharon Goh
Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer, infectious diseases, or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with preferred embodiment of a bispecific antibody against TIM-3 and CD3.
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公开(公告)号:US10167338B2
公开(公告)日:2019-01-01
申请号:US15229336
申请日:2016-08-05
Applicant: Agency for Science, Technology and Research
Inventor: Cheng-I Wang , Peter Brauer , Siok Ping Yeo , Hwee Ching Tan , John Edward Connolly
Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
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