公开(公告)号：US20190144535A1

公开(公告)日：2019-05-16

申请号：US16192537

申请日：2018-11-15

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-l Wang ,  Angeline Goh ,  Siok Ping Yeo ,  Alessandra Mortellaro ,  Subhra Kumar Biswas ,  Florent Ginhoux ,  Pingyu Zhong

IPC: C07K16/24

Abstract: The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.

公开(公告)号：US20170226211A1

公开(公告)日：2017-08-10

申请号：US15486468

申请日：2017-04-13

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-I Wang ,  Eve Ngoh ,  Siok Ping Yeo

IPC: C07K16/28 ,  A61K9/00

CPC classification number: C07K16/2818 ,  A61K9/0019 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: Anti-CTLA-4 antibodies are disclosed. Also disclosed are compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US10472421B2

公开(公告)日：2019-11-12

申请号：US15750425

申请日：2016-08-05

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I Wang ,  Peter Brauer ,  Siok Ping Yeo ,  Hwee Ching Tan ,  John Edward Connolly

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  C07K16/10 ,  A61K39/00 ,  A61K38/17

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US10435466B2

公开(公告)日：2019-10-08

申请号：US15521514

申请日：2015-10-27

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-i Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo ,  Yun Pei Sharon Goh

IPC: C07K16/28 ,  A61K39/395

Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer or infectious disease or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with a preferred embodiment of a bispecific antibody against TIM-3 and CD3.

公开(公告)号：US20190292261A1

公开(公告)日：2019-09-26

申请号：US16360445

申请日：2019-03-21

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-I Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo ,  Jianrong Lionel Low ,  Hwee Ching Tan

IPC: C07K16/28 ,  C07K16/00

Abstract: Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US10246512B2

公开(公告)日：2019-04-02

申请号：US15922921

申请日：2018-03-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I Wang ,  Peter Brauer ,  Siok Ping Yeo ,  Hwee Ching Tan ,  John Edward Connolly

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  C07K16/10 ,  A61K39/00 ,  A61K38/17

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US20180362655A1

公开(公告)日：2018-12-20

申请号：US16112008

申请日：2018-08-24

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I Wang ,  Peter Brauer ,  Siok Ping Yeo ,  Hwee Ching Tan ,  John Edward Connolly

IPC: C07K16/28 ,  C07K16/10 ,  A61K39/395 ,  C07K16/46 ,  A61K47/68 ,  A61K39/00 ,  A61K38/17

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US20170319690A1

公开(公告)日：2017-11-09

申请号：US15623679

申请日：2017-06-15

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-i Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo

IPC: A61K39/395 ,  G01N33/574 ,  A61K45/06 ,  G01N33/53 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/53 ,  G01N33/57484 ,  G01N2800/52 ,  Y02A50/41 ,  Y02A50/412

Abstract: Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US20170240633A1

公开(公告)日：2017-08-24

申请号：US15521685

申请日：2015-10-27

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-i Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo ,  Yun Pei Sharon Goh

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/30

CPC classification number: C07K16/2803 ,  C07K16/2809 ,  C07K16/3061 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92

Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer, infectious diseases, or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with preferred embodiment of a bispecific antibody against TIM-3 and CD3.

公开(公告)号：US20240052046A1

公开(公告)日：2024-02-15

申请号：US18344711

申请日：2023-06-29

Applicant: Agency for Science, Technology and Research ,  Euchloe Bio Pte. Ltd.

Inventor： Peter Brauer ,  John Edward Connolly ,  Richard Hopkins ,  Junyun Lai ,  Jianrong Lionel Low ,  Kar Wai Tan ,  Cheng-I Wang ,  Siok Ping Yeo

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K16/468 ,  C07K2317/565 ,  C07K2317/75

Abstract: Antigen binding molecules capable of binding to CDI22 and/or common y′ chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.