公开(公告)号：US20060235351A1

公开(公告)日：2006-10-19

申请号：US11195351

申请日：2005-08-02

申请人： Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Kazuyuki Tsuji ,  Tsutomu Shibata ,  Akihiko Tanioka ,  Mie Minagawa

发明人： Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Kazuyuki Tsuji ,  Tsutomu Shibata ,  Akihiko Tanioka ,  Mie Minagawa

IPC分类号： A61N1/30 ,  A61K31/785 ,  A61K31/717

CPC分类号： A61N1/0444 ,  A61K9/0009 ,  A61K9/7023

摘要： The administration efficiency of a drug may be improved by establishing compatibility between the suppression of the release of a biological counter ion from a living body's biological interface and the maintenance of a good state of contact between each of a working electrode structure and a nonworking electrode structure and the biological interface. Coating films each composed of an external preparation containing: a hydrophilic polymer matrix agent; and an ion-exchange resin dispersed in the hydrophilic polymer matrix agent, or coating films each composed of an external preparation containing a hydrophilic polymer having an ion-exchange function are formed on the biological interface, and iontophoresis is performed through the coating films.

摘要翻译： 药物的给药效率可以通过建立抑制生物体离子从活体生物界面的释放与维持工作电极结构和非工作电极结构之间的良好接触状态之间的相容性来改善 和生物界面。 涂膜各自由外用制剂组成，含有：亲水性聚合物基质剂; 在亲水性聚合物基质剂中分散有离子交换树脂，或者在生物界面上形成各自由含有具有离子交换功能的亲水性聚合物的外用制剂构成的涂膜，通过涂膜进行离子电渗疗法。

公开(公告)号：US07437189B2

公开(公告)日：2008-10-14

申请号：US11196783

申请日：2005-08-02

申请人： Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Tsutomu Shibata ,  Akihiko Tanioka

发明人： Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Tsutomu Shibata ,  Akihiko Tanioka

IPC分类号： A61N1/30 ,  A61M5/32

CPC分类号： A61N1/306

摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.

摘要翻译： 离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透 第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

公开(公告)号：US20070003803A1

公开(公告)日：2007-01-04

申请号：US10553702

申请日：2004-04-16

申请人： Ryushin Omasa ,  Akihiko Tanioka ,  Mie Minagawa

发明人： Ryushin Omasa ,  Akihiko Tanioka ,  Mie Minagawa

IPC分类号： H01M8/18 ,  C01B31/20 ,  H01M8/06

CPC分类号： H01M8/0656

摘要： A single cell comprising a fuel electrode, an air electrode, and an electrolytic layer or hollow layer interposed between those electrodes, or a fuel cell comprised of a stack of these single cells, wherein a supply port is formed on the fuel electrode side for supplying a hydrogen-based/oxygen-based mixed gas obtained by electrolyzing an electrolyte fluid by agitating and stirring and collecting the resulting gas; moreover the fuel electrode to which the hydrogen-based/oxygen-based mixed gas is supplied is gas-permeable. The hydrogen-based/oxygen-based mixed gas contains H, H2, H3, and/or HD, OH, 16O, and O2.

摘要翻译： 单电池，其包括燃料电极，空气电极，以及介于这些电极之间的电解质层或中空层，或由这些单体电池堆叠构成的燃料电池，其中在燃料电极侧形成供给口供给 通过搅拌和收集所得气体来电解电解质液体获得的氢基/氧基混合气体; 此外，供给氢基/氧基混合气体的燃料电极是透气性的。 氢基/氧基混合气体含有H，H 2 H 3，H 3和/或HD，OH，16 O， 和O 2。

公开(公告)号：US20060217654A1

公开(公告)日：2006-09-28

申请号：US11196783

申请日：2005-08-02

申请人： Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Tsutomu Shibata ,  Akihiko Tanioka

发明人： Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Tsutomu Shibata ,  Akihiko Tanioka

IPC分类号： A61N1/30

CPC分类号： A61N1/306

摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.

摘要翻译： 离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透 第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

公开(公告)号：US20060129085A1

公开(公告)日：2006-06-15

申请号：US11172372

申请日：2005-06-30

申请人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： An iontophoresis device for administering drug ions via the first ion-exchange membrane, comprising a first semi-permeable film having a number of pores passing through the film from a front surface to a back surface, a first ion-exchange membrane formed of ion-exchange resin filling the pores of the first semi-permeable film and selective ions of a first polarity, and a working electrode structure having a drug holding part placed on a back surface of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity, wherein a layer of a water-soluble polymer compound chemically bonded on the surface of the first semi-permeable film.

摘要翻译： 1.一种用于经由第一离子交换膜施用药物离子的离子电渗疗法装置，其特征在于，具有从前表面到背面通过所述膜的多孔的第一半透膜，由离子交换膜形成的第一离子交换膜， 填充第一半透膜的孔和第一极性的选择性离子的交换树脂，以及具有放置在第一离子交换膜的背面上的药物保持部并保持含有药物离子的药液的工作电极结构 以第一极性充电，其中化学键合在第一半透膜上的水溶性高分子化合物层。

公开(公告)号：US07660626B2

公开(公告)日：2010-02-09

申请号：US11195364

申请日：2005-08-02

申请人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

公开(公告)号：US20070157880A1

公开(公告)日：2007-07-12

申请号：US10546008

申请日：2004-02-19

申请人： Akihiko Tanioka ,  Yutaka Yamagata ,  Kozo Inoue

发明人： Akihiko Tanioka ,  Yutaka Yamagata ,  Kozo Inoue

IPC分类号： B05C5/02

CPC分类号： B05B5/087 ,  B05B5/025

摘要： An immobilization method, an apparatus, and a manufacturing method of a microstructure are provided, where the method including the electrospray step by which a solution containing at least one objective substance is supplied to a capillary; and immobilization step by which the objective substance in the solution atomized in the electrospray step is immobilized on an object, which is to be coated and has an arbitrary shape, in a dried state by an electrostatic force while retaining functionality and/or activity of the objective substance, resulting in a thickness on the order of nanometers.

摘要翻译： 提供一种微结构的固定方法，装置和制造方法，其中包括将含有至少一种目标物质的溶液供给毛细管的电喷雾步骤的方法; 以及固定步骤，其中在电喷雾步骤中雾化的溶液中的目标物质通过静电力固定在被涂覆并具有任意形状的物体上，同时保持其的功能和/或活性 目标物质，导致纳米级的厚度。

公开(公告)号：US20060173401A1

公开(公告)日：2006-08-03

申请号：US11195364

申请日：2005-08-02

申请人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minagawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。