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公开(公告)号：US08846607B2
公开(公告)日：2014-09-30
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译： 已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘 。 制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。 通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。 在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。 在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。 任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。 制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。 制剂优选作为肺制剂施用。 在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。 在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。
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公开(公告)号：US20140224248A1
公开(公告)日：2014-08-14
申请号：US14115941
申请日：2012-05-11
IPC分类号： A61M15/00
CPC分类号： A61M15/0021 , A23P10/40 , A61M11/002 , A61M15/002 , A61M15/06 , A61M2202/064 , A61M2210/0625
摘要： Aerosolized particles in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and particles can allow for the aerosolization of the particles and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The particle delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized particles (e.g., food particles) in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译： 在确定的粒度范围内的气溶胶颗粒悬浮在空气中并沉积在口中而不容易进入呼吸道。 包含气溶胶产生装置和颗粒的装置可以允许以适于吸入或沉积并随后摄入的方式使颗粒雾化和输送。 颗粒递送装置代表用于将食物输送到人和动物口中的新颖手段。 实际上，本发明的装置被设计成以悬浮在空气中的确定的大小范围内产生，运输和直接雾化的颗粒（例如，食物颗粒），以便沉积在口中而不会大量暴露或进入呼吸道。
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公开(公告)号：US08628754B2
公开(公告)日：2014-01-14
申请号：US13334236
申请日：2011-12-22
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。
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14.发明授权Method and apparatus allowing scan of data storage device from remote server 有权允许从远程服务器扫描数据存储设备的方法和装置公开(公告)号：US08489686B2
公开(公告)日：2013-07-16
申请号：US12785131
申请日：2010-05-21
申请人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
发明人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
IPC分类号： G06F15/16
摘要： A method and device allowing a scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an out-of-band (OOB) configured to compute a first hash value for data stored in one or more sectors of a data storage device at a first time; receive, using communication circuitry, a request to transmit a portion of the data stored in the one or more sectors of the data storage device at a second time, the second time being subsequent to the first time; compute a second hash value for the data stored in the one or more sectors of the data storage device at the second time; and transmit, using the communication circuitry, the requested portion of the data, only if the second hash value does not match the first hash value.
摘要翻译： 公开了允许从远程服务器扫描数据存储设备的方法和设备。 在一些实施例中，计算设备可以包括带外（OOB），其被配置为在第一时间对存储在数据存储设备的一个或多个扇区中的数据计算第一散列值; 接收使用通信电路的请求，以在第二时间之后的第二时间第二时间发送存储在数据存储装置的一个或多个扇区中的数据的一部分的请求; 在第二次计算存储在数据存储设备的一个或多个扇区中的数据的第二哈希值; 并且仅当所述第二散列值与所述第一散列值不匹配时，才使用所述通信电路来发送所请求的数据部分。
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公开(公告)号：US20130045246A1
公开(公告)日：2013-02-21
申请号：US13580629
申请日：2011-02-22
CPC分类号： B05D3/002 , A23L29/256 , A23P10/30 , A23P20/105 , A23P20/15 , A23P20/17 , A23P20/20 , A23P20/25 , B05D2350/60 , B05D2401/20
摘要： Edible or potable substances can be transported in biodegradable vessel.
摘要翻译： 食用或饮用物质可以在可生物降解的容器中运输。
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公开(公告)号：US08281043B2
公开(公告)日：2012-10-02
申请号：US12836341
申请日：2010-07-14
CPC分类号： G06F3/0604 , G06F3/0617 , G06F3/0659 , G06F3/067
摘要： A method, apparatus, system, and computer program product for enabling out-of-band access to storage devices through port-sharing hardware. Providing out-of-band access to storage devices enables system management functions to be performed when an operating system is non-functional as well as when the operating system is active. Storage commands originating with a management service can be interleaved with storage commands issued by the host operating system. The host operating system maintains ownership and control over its storage devices, but management activities can be performed while the host operating system is operational.
摘要翻译： 一种用于通过端口共享硬件对存储设备进行带外访问的方法，装置，系统和计算机程序产品。 提供对存储设备的带外访问可使系统管理功能在操作系统不起作用以及操作系统处于活动状态时执行。 源自管理服务的存储命令可以与主机操作系统发出的存储命令交错。 主机操作系统维护对其存储设备的所有权和控制权，但是可以在主机操作系统运行时执行管理活动。
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公开(公告)号：USD662201S1
公开(公告)日：2012-06-19
申请号：US29336932
申请日：2009-05-12
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公开(公告)号：USD659819S1
公开(公告)日：2012-05-15
申请号：US29352274
申请日：2009-12-18
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公开(公告)号：US20120114809A1
公开(公告)日：2012-05-10
申请号：US13132469
申请日：2009-12-03
CPC分类号： A61M11/005 , A61M11/002 , A61M15/0025 , A61M15/06
摘要： Aerosolized food products in a determined particle size range are suspended in the air and deposited in the mouth without easily entering into the respiratory tract. An apparatus incorporating an aerosol generating device and food products can allow for the aerosolization of the food products and the delivery thereof in a manner suitable for inhalation or deposition and subsequent ingestion. The food delivery apparatus represents a novel means for delivering food to the mouths of humans and animals. Indeed, the apparatus of the invention is designed to produce, transport, and direct aerosolized food particles in a determined size range, suspended in air, to be deposited in the mouth without substantial exposure or entry into the respiratory tract.
摘要翻译： 确定粒度范围的气溶胶食品悬浮在空气中并沉积在口中，而不会容易地进入呼吸道。 包含烟雾发生装置和食品的装置可以允许以适合于吸入或沉积并随后摄取的方式使食品雾化和输送。 食物输送装置代表将食物输送到人类和动物口腔的新颖手段。 实际上，本发明的装置被设计成生产，运输和引导悬浮在空气中的确定尺寸范围的雾化食物颗粒，以便沉积在口中而不会大量暴露或进入呼吸道。
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20.再颁专利Compositions and methods for enhancing receptor-mediated cellular internalization 失效用于增强受体介导的细胞内化的组合物和方法公开(公告)号：USRE42072E1
公开(公告)日：2011-01-25
申请号：US11821514
申请日：2007-06-21
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译： 公开了用于改善一种或多种化合物的细胞内化的组合物和方法。 组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。 该组合物还包括或与其结合使用，其量可以有效地最大化受体的表达或结合，并增强化合物进入细胞的RME。 这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。 组合物经口，鼻，阴道，直肠和眼部局部应用。 增强剂与组合物一起施用或分开施用，全部或优选局部施用。 待递送的化合物也可以是增强剂。
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