公开(公告)号：US4383112A

公开(公告)日：1983-05-10

申请号：US167158

申请日：1980-07-08

Applicant: Dale A. Laidler ,  David J. Milner

Inventor： Dale A. Laidler ,  David J. Milner

IPC: B01J31/00 ,  C07B61/00 ,  C07D207/09 ,  C07D207/32 ,  C07D207/323 ,  C07D213/53 ,  C07D215/12 ,  C07F11/00 ,  C07F15/04 ,  C07D213/00 ,  C07D215/00

CPC classification number: C07D207/323 ,  C07D213/53 ,  C07D215/12

Abstract: Chiral Schiff bases according to the general formula: ##STR1## and transition metal complexes thereof, wherein C.sup.* is an asymmetric carbon atom, R.sup.1 and R.sup.2, which may be the same or different are alkyl, aralkyl, aryl or alkaryl, R.sup.3 is hydrogen, alkyl, aralkyl, aryl or alkaryl, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or lower alkyl or, where n is 1, may with the cyclic ring to which CR.sup.4 R.sup.5 is attached form a fused system, J is a chain of 3 or 4 atoms which may all be carbon atoms or may be a mixture of carbon atoms and one or more hetero atoms which may be the same or different, which chain with the group C K forms an aromatic system, K is nitrogen, ##STR2## or --NH--, L, each of which may be the same or different, represents a substituent attached to a carbon atom in the chain J and is hydrogen, alkyl, aralkyl, alkaryl, aryl or a substituent containing a hetero-atom; or two L's together with the cyclic ring to which they are attached form a fused system, n is 0, 1 or 2, m is the number of carbon atoms in the chain J. The transition metal is for example copper (II), chromium (II), manganese (II), iron (II), cobalt (II) nickel (II) or palladium (II). The aforesaid complexes may be used as catalysts in the cyclopropanation of olefins by diazoacetates to form insecticide or insecticide precursors.

Abstract translation: 手性席夫碱，其通式为：其中C *为不对称碳原子，其中R 1和R 2可以相同或不同，为烷基，芳烷基，芳基或烷芳基，R 3为氢 烷基，芳烷基，芳基或烷芳基，R 4和R 5可以相同或不同，为氢或低级烷基，或其中n为1，可以与CR4R5连接的环上形成稠合体系，J为 3或4个原子的链可以全部是碳原子，或者可以是碳原子和一个或多个可以相同或不同的杂原子的混合物，该基团与基团CK形成芳族体系，K是氮， 或者-NH-，L各自可以相同或不同，表示连接在J链上的碳原子上的取代基，是氢，烷基，芳烷基，烷芳基，芳基或含杂原子的取代基， 原子; 或两个L 3与它们所连接的环状基团一起形成稠合体系，n为0,1或2，m为链J中的碳原子数。过渡金属为例如铜（II），铬 （II），锰（II），铁（II），钴（II）镍（II）或钯（II）。 上述络合物可以用作催化剂，通过重氮乙酸酯将烯烃环丙烷化形成杀虫剂或杀虫剂前体。

公开(公告)号：US4332962A

公开(公告)日：1982-06-01

申请号：US238950

申请日：1981-02-27

Applicant: David J. Milner ,  David Holland

Inventor： David J. Milner ,  David Holland

IPC: C07C69/74 ,  B01J27/00 ,  B01J27/12 ,  B01J31/00 ,  B01J31/04 ,  C07B61/00 ,  C07C59/00 ,  C07C67/00 ,  C07C67/30 ,  C07C69/743 ,  C07D307/45

CPC classification number: C07C2101/02

Abstract: Process for the preparation of 3(2,2-dihalovinyl)-2,2-dimethyl cyclopropane carboxylic acids, especially permethrin acid ethyl ester, by reacting a diazoacetic acid ester with a 1,1-dihalo-4-methyl-1,3-pentadiene in the presence of a catalyst comprising a divalent rhodium salt of a carboxylic acid or borofluoric acid. The products have improved yields and better cis/trans isomer ratios than when the more common catalysts, e.g. copper-bronze, are used.

Abstract translation: 制备3（2,2-二卤代乙烯基）-2,2-二甲基环丙烷羧酸，特别是氯菊酯酸乙酯的方法是使重氮乙酸酯与1,1-二卤代-4-甲基-1,3- - 戊二烯在包含羧酸或硼氟酸的二价铑盐的催化剂存在下进行。 与更常见的催化剂，例如，较好的催化剂相比，产物具有提高的产率和更好的顺式/反式异构体比例。 铜青铜被使用。

公开(公告)号：US4228107A

公开(公告)日：1980-10-14

申请号：US40047

申请日：1979-05-17

Applicant: David Holland ,  David J. Milner ,  Roger K. Huff

Inventor： David Holland ,  David J. Milner ,  Roger K. Huff

IPC: A01N29/02 ,  A01N53/00 ,  B01J27/00 ,  C07C17/00 ,  C07C17/275 ,  C07C19/00 ,  C07C19/01 ,  C07C19/07 ,  C07C19/075 ,  C07C19/08 ,  C07C19/10 ,  C07C19/14 ,  C07C67/00

CPC classification number: C07C19/14 ,  A01N53/00 ,  C07C17/275 ,  C07C19/10

Abstract: Polyhalogenated hydrocarbons of general formula RR.sup.1 CH--CHX--CH.sub.2 CYZQ wherein R is hydrogen or lower alkyl, R.sup.1 is lower alkyl, X is Cl, Br or I, Y is F, Cl or Br, Z is Y or Q and Q is a group W(CF.sub.2).sub.m --in which W is hydrogen, F or Cl and m is 1 or 2, provided that X is always Br or I when at least one of Y and Z is Br, and a process for preparing these polyhalogenated hydrocarbons by reacting an alkyl-substituted butene with a polyhalogenated alkane having from 2 to 4 carbon atoms, in the presence of a catalyst.

Abstract translation: 通式为RR1CH-CHX-CH2CYZQ的多卤代烃，其中R为氢或低级烷基，R1为低级烷基，X为Cl，Br或I，Y为F，Cl或Br，Z为Y或Q，Q为基团W （CF 2）m-其中W是氢，F或Cl，m是1或2，条件是当Y和Z中的至少一个是Br时X总是Br或I，以及通过使 烷基取代的丁烯与具有2至4个碳原子的多卤代烷烃在催化剂存在下反应。

公开(公告)号：US5334744A

公开(公告)日：1994-08-02

申请号：US995861

申请日：1992-12-23

Applicant: Ernest S. Cleugh ,  David J. Milner

Inventor： Ernest S. Cleugh ,  David J. Milner

IPC: C07B55/00 ,  C07B57/00 ,  C07B63/00 ,  C07C253/00 ,  C07C253/30 ,  C07C253/32 ,  C07C255/38 ,  C07C255/39 ,  C07C253/34

CPC classification number: C07C255/38

Abstract: A process for obtaining an isomer of a compound of general formulaR--CH(CN)--R' (I)wherein each of R and R' may be any organic radical linked directly or through a heteroatom to the carbon atom bearing the cyano group provided that at least one of R and R' comprises at least one resolved chiral center which is stable under the conditions of the process, or a racemic modification comprising the isomer and its enantiomer, which comprises the step of treating the epimer of the isomer, or the racemate comprising the epimer and the enantiomer of the epimer, in solution in a polar organic solvent, or in slurry in a polar organic liquid diluent in which the epimer or the racemate is partially soluble, with a source of cyanide ions, in the absence of a base, the isomer, or the racemic modification comprising the isomer and its enantiomer, being less soluble in the solvent or diluent than the epimer of the isomer, or the racemate comprising the epimer of the isomer and the enantiomer of the epimer, respectively.

Abstract translation: 获得通式为R-CH（CN）-R'（I）的化合物的异构体的方法，其中R和R'各自可以是直接或通过杂原子与带有氰基的碳原子连接的任何有机基团 条件是R和R'中的至少一个包含至少一个在该方法的条件下是稳定的拆分的手性中心，或包含异构体及其对映异构体的外消旋体，其包括处理异构体的差向异构体的步骤， 或包含差向异构体和差向异构体的对映异构体的外消旋物，在极性有机溶剂中的溶液中，或在极性有机液体稀释剂中的浆液中，其中差向异构体或外消旋体部分可溶于氰化物离子源 不含碱基，异构体或包含异构体及其对映异构体的外消旋体，比异构体的差向异构体更难溶于溶剂或稀释剂，或包含异构体的差向异构体和epim对映异构体的外消旋体 呃。

公开(公告)号：US5214161A

公开(公告)日：1993-05-25

申请号：US898833

申请日：1992-06-15

Applicant: David J. Milner

Inventor： David J. Milner

IPC: C07D307/83 ,  C07C201/12 ,  C07C205/56 ,  C07D493/04 ,  C09B57/00

CPC classification number: C07D493/04 ,  C09B57/00

Abstract: A process for the preparation of a polycyclic dye of the Formula (1): ##STR1## by reacting a ketal ester of the Formula (2): ##STR2## with a benzofuranone of the Formula (3): ##STR3## wherein: Ring A is unsubstituted or is substituted by from one to three groups:Ring B is unsubstituted, apart from the nitro group, or is substituted by one or two additional groups;each R is independently alkyl.The polycyclic dyes described are useful for the coloration of synthetic textile materials especially polyesters.

公开(公告)号：US4350811A

公开(公告)日：1982-09-21

申请号：US166838

申请日：1980-07-08

Applicant: David Holland ,  David J. Milner

Inventor： David Holland ,  David J. Milner

IPC: C07C69/608 ,  C07F1/00 ,  C07H15/12 ,  C07H15/18 ,  C07H15/26 ,  C07H17/02 ,  C07H17/04 ,  C07H23/00

CPC classification number: C07H15/12 ,  C07F1/005

Abstract: Chiral Schiff bases according to the general formula: ##STR1## and chiral transition metal complexes thereof, wherein at least the carbon atom of the monosaccharide to which the iminyl nitrogen atom is attached is asymmetric, and at least one of the carbon atoms adjacent the aforesaid carbon atom bears a hydroxyl group, R.sup.1 and R.sup.6 which may be the same or different, are hydrogen or lower alkyl, R.sup.2 is hydrogen, or lower alkyl or together with R.sup.10 forms a divalent hydrocarbon group, R.sup.3 is hydrogen, a sugar residue, or --CH.sub.2 OR.sup.10 in which R.sup.10 is hydrogen, lower alkyl or together with R.sup.2 forms a divalent hydrocarbon group, R.sup.4 is hydrogen or --CH.sub.2 OR.sup.10 in which R.sup.10 is hydrogen, or a lower alkyl, R.sup.5 is hydrogen, OR.sup.1 or a sugar residue, provided that both R.sup.4 and R.sup.5 are not hydrogen, R.sup.7 and R.sup.8 which may be the same or different, are hydrogen, or lower alkyl, or where p is 1, may with the cyclic ring to which CR.sup.7 R.sup.8 is attached form a fused system, R.sup.9 is hydrogen, alkyl, aralkyl, aryl or alkaryl, J is a chain of 3 or 4 atoms which with the group C A forms an aromatic system, which atoms may be carbon atoms or may be a mixture of carbon and one or more hetero atoms which may be the same or different, A is nitrogen, or ##STR2## or --NH--, L each of which may be the same or different, represents a substituent attached to a carbon atom in the chain J and is hydrogen, an alkyl group, aralkyl group, aryl, alkaryl or a substituent containing a hetero-atom; or two L's together with cyclic group to which they are attached form a fused system, m is 0 or 1, n is 0, 1 or 2, provided that n plus m is 0, 1, 2 or 3, p is 0, 1 or 2 and q is the number of carbon atoms in the chain J. The transistion metal is for example copper (II), chromium (II), manganese (II), iron (II), cobalt (II), nickel (II) or palladium (II). The aforesaid complexes may be used as catalysts in the cyclopropanation of olefins by diazoacetates to form insecticide or insecticide precursors.