公开(公告)号：US10662135B2

公开(公告)日：2020-05-26

申请号：US16571948

申请日：2019-09-16

申请人： Honeywell International Inc.

发明人： Christian Jungong ,  Haiyou Wang ,  Daniel C. Merkel ,  Hang T. Pham ,  Ryan J. Hulse

IPC分类号： C07C21/00 ,  C07C19/00 ,  C07C21/18 ,  C07C19/16

摘要： The present disclosure provides azeotrope or azeotrope-like compositions including trifluoroiodomethane (CF3I) and hexafluoroacetone (HFA), and a method of forming an azeotrope or azeotrope-like composition comprising the step of combining hexafluoroacetone (HFA) and trifluoroiodomethane (CF3I) to form an azeotrope or azeotrope-like comprising hexafluoroacetone (HFA) and trifluoroiodomethane (CF3I) having a boiling point of about −29.84° C.±0.30° C. at a pressure of about 14.40 psia±0.30 psia.

公开(公告)号：US10240184B2

公开(公告)日：2019-03-26

申请号：US15376139

申请日：2016-12-12

申请人： Promega Corporation

发明人： Keith V. Wood ,  Georgyi V. Los ,  Robert F. Bulleit ,  Dieter Klaubert ,  Mark McDougall ,  Chad Zimprich

IPC分类号： C07C19/00 ,  C12Q1/34 ,  C12N9/14 ,  C12N9/86 ,  G01N33/50 ,  G01N33/58 ,  C07C217/08 ,  C07C271/16 ,  C07D209/48 ,  C07D233/64 ,  C07D311/78 ,  C07D311/82 ,  C07D405/06 ,  C07D493/10 ,  C07D495/04 ,  C07F5/02

摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.

公开(公告)号：US09802972B2

公开(公告)日：2017-10-31

申请号：US14896412

申请日：2014-06-06

申请人： LANXESS Deutschland GmbH

发明人： Zhenli Wei ,  Qingchun Liu

IPC分类号： C07C19/00 ,  C07F15/00 ,  B01J31/22 ,  C08C19/02 ,  C08L15/00 ,  C07C5/03 ,  C08F236/12

CPC分类号： C07F15/0046 ,  B01J31/2217 ,  B01J31/2243 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/645 ,  B01J2531/821 ,  B01J2531/825 ,  C07C5/03 ,  C07C2531/22 ,  C08C19/02 ,  C08F236/12 ,  C08L15/005 ,  C07C9/15

摘要： The present invention provides novel ruthenium or osmium based complex structures with a unique combination of ligands comprising a Schiff-base type ligand, a N-heterocyclic carbene ligand and a CO ligand which can be prepared according to two different routes involving easily accessible starting materials and which represent excellent catalysts for hydrogenating unsaturated compounds, oligomers and polymers, in particular at unforeseeably low temperatures.

公开(公告)号：US08895787B2

公开(公告)日：2014-11-25

申请号：US13450233

申请日：2012-04-18

申请人： Keith V. Wood ,  Georgyi V. Los ,  Robert F. Bulleit ,  Dieter Klaubert ,  Mark McDougall ,  Chad Zimprich

发明人： Keith V. Wood ,  Georgyi V. Los ,  Robert F. Bulleit ,  Dieter Klaubert ,  Mark McDougall ,  Chad Zimprich

IPC分类号： C07C19/00 ,  C07C21/00 ,  G01N33/53 ,  C12Q1/34 ,  C12N9/24

CPC分类号： C12Q1/34 ,  C07C217/08 ,  C07C271/16 ,  C07D209/48 ,  C07D233/64 ,  C07D311/78 ,  C07D311/82 ,  C07D405/06 ,  C07D493/10 ,  C07D495/04 ,  C07F5/022 ,  C12N9/14 ,  C12N9/86 ,  C12Y308/01005 ,  G01N33/5005 ,  G01N33/58 ,  Y10S436/80

摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.

摘要翻译： 提供任选融合到感兴趣的蛋白质的突变体水解酶。 突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定。 还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。 还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。

公开(公告)号：US08809451B2

公开(公告)日：2014-08-19

申请号：US13201766

申请日：2010-02-18

申请人： Yoshimi Isono ,  Satoru Narizuka ,  Hidehisa Nanai ,  Kazuhiro Yamanaka

发明人： Yoshimi Isono ,  Satoru Narizuka ,  Hidehisa Nanai ,  Kazuhiro Yamanaka

IPC分类号： B01F17/00 ,  C07C17/00 ,  C07C19/00 ,  C07C19/08 ,  C07C21/00 ,  C07C22/00 ,  C07C23/00 ,  C07C25/00 ,  C07C25/13 ,  C07C69/00 ,  C07C69/34 ,  C07C69/52 ,  C07C69/63 ,  C08G18/42 ,  C08G63/00 ,  C08G63/02 ,  C08G63/60 ,  C08G63/68 ,  C08G63/682 ,  C08G67/00 ,  C08G69/00 ,  C08G69/26 ,  C08L67/00 ,  C08L67/02 ,  C08L73/00 ,  C08L77/00 ,  C08L79/00

CPC分类号： C07C59/64 ,  C07C69/65 ,  C07C69/734 ,  C08G63/6826 ,  C08G69/42 ,  C08G73/06 ,  C08G73/1039 ,  C08G73/22

摘要： According to the present invention, a polymer is obtained by polycondensation of a fluorinated dicarboxylic acid derivative of the general formula (M-1) or an acid anhydride of the fluorinated dicarboxylic acid with a polyfunctional compound having two to four reactive groups corresponding in reactivity to carbonyl moieties of the fluorinated dicarboxylic acid derivative or acid anhydride. [Chem. 134] AOCF2C-Q-CF2COA′  (M-1) In the above formula, Q represents a divalent organic group having a substituted or unsubstituted aromatic ring; and A and A′ each independently represent an organic group. This polymer exhibits a sufficiently low dielectric constant for use as a semiconductor protection film and has the capability of forming a film at a relatively low temperature of 250° C. or lower.

摘要翻译： 根据本发明，通过使通式（M-1）的氟化二羧酸衍生物或氟化二羧酸的酸酐与具有2〜4个反应性对应的反应性基团的多官能化合物与反应性对应的反应性缩聚得到聚合物 氟化二羧酸衍生物或酸酐的羰基部分。 [Chem。 134] AOCF2C-Q-CF2COA'（M-1）在上式中，Q表示具有取代或未取代的芳环的二价有机基团; A和A'各自独立地表示有机基团。 该聚合物表现出足够低的介电常数用作半导体保护膜，并且具有在250℃或更低的较低温度下形成膜的能力。

公开(公告)号：US08765011B2

公开(公告)日：2014-07-01

申请号：US13468779

申请日：2012-05-10

申请人： Teizi Satou ,  Yasuyuki Goto

发明人： Teizi Satou ,  Yasuyuki Goto

IPC分类号： C09K19/06 ,  C09K19/52 ,  C09K19/34 ,  C09K19/32 ,  C09K19/30 ,  C09K19/12 ,  C09K19/00 ,  C07C17/00 ,  C07C23/00 ,  C07C19/00 ,  C07C21/00

CPC分类号： C07C22/00 ,  C09K19/3003 ,  C09K2019/0444 ,  C09K2019/3004 ,  C09K2019/3009 ,  C09K2019/3016 ,  C09K2019/3036 ,  C09K2019/3078 ,  C09K2019/3422

摘要： To provide a liquid crystal compound having general physical properties required for the compound, namely, a high stability to heat, light and so forth, a small viscosity, a refractive index anisotropy value having a suitable magnitude, a dielectric constant anisotropy value having a suitable magnitude and steep electro-optical characteristics, a wide temperature range of a nematic phase, and an excellent compatibility with other liquid crystal compounds, in particular, a liquid crystal compound having a wide temperature range of the nematic phase; the compound is represented by formula (1): wherein R is alkenyl having 2 to 20 carbons; ring A1 and ring A2 are independently 1,4-cyclohexylene, or 1,4-phenylene in which at least one of hydrogen may be replaced by fluorine; Z1 and Z2 are independently a single bond, —CH2CH2—, —CH═CH—, —CH2O— or —OCH2—; and n is 0 or 1.

摘要翻译： 为了提供具有化合物所需的一般物理性能的液晶化合物，即对热，光等具有高稳定性，具有适当大小的粘度小，折射率各向异性值，具有合适的介电常数各向异性值 幅度和陡峭的电光特性，向列相的宽温度范围，以及与其它液晶化合物，特别是具有宽的向列相温度范围宽的液晶化合物的相容性优异。 该化合物由式（1）表示：其中R是具有2至20个碳的烯基; 环A1和环A2独立地为1,4-亚环己基或其中至少一个氢可被氟取代的1,4-亚苯基; Z 1和Z 2独立地是单键，-CH 2 CH 2 - ， - CH = CH - ， - CH 2 O-或-OCH 2 - ; n为0或1。

公开(公告)号：US08168405B2

公开(公告)日：2012-05-01

申请号：US13046297

申请日：2011-03-11

申请人： Aldis Darzins ,  Lance Encell ,  Dieter Klaubert ,  Georgyi V. Los ,  Mark McDougall ,  Keith V. Wood ,  Monika G. Wood ,  Chad Zimprich

发明人： Aldis Darzins ,  Lance Encell ,  Dieter Klaubert ,  Georgyi V. Los ,  Mark McDougall ,  Keith V. Wood ,  Monika G. Wood ,  Chad Zimprich

IPC分类号： G01N33/53 ,  C12Q1/34 ,  C12N9/14 ,  C12P21/02 ,  C07C19/00

CPC分类号： G01N33/581 ,  C07K7/06 ,  C07K16/00 ,  C07K2317/622 ,  C07K2319/43 ,  C07K2319/61 ,  C09B1/00 ,  C09B11/24 ,  C09B23/04 ,  C09B23/06 ,  C09B23/105 ,  C12N9/14 ,  C12Q1/34 ,  C12Y308/01005 ,  G01N33/573 ,  G01N2333/914 ,  Y10S530/825

摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.

摘要翻译： 提供任选融合到感兴趣的蛋白质的突变体水解酶。 突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定，并且相对于野生型水解酶具有至少两个氨基酸取代 野生型水解酶。 还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。 还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。

公开(公告)号：US07842730B2

公开(公告)日：2010-11-30

申请号：US10591411

申请日：2005-02-07

申请人： Irina Nikolaievna Kuznetsova ,  Evgeny Ilich Maievsky

发明人： Irina Nikolaievna Kuznetsova ,  Evgeny Ilich Maievsky

IPC分类号： A01N43/36 ,  A01N29/02 ,  A61K31/40 ,  A61K31/02 ,  C07C19/08 ,  C07C22/00 ,  C07C25/13 ,  C07C19/00 ,  C07C21/00 ,  C07C21/18

CPC分类号： A61K9/0026 ,  A61K9/107 ,  A61K31/02

摘要： Medicine, in particular medications for treating blood losses, hypoxic and ishemic states, for improving a blood oxygen supply and for preserving isolated perfused organs and tissues. The inventive medical emulsion of perfluororganic compounds includes rapidly excretable perfluororganic compounds such as perfluordecalin, perfluoractilbromide, a perfluoroganic additive embodied in the form of a mixture of perfluorinated tertiary amines and phospholipids in the form of a water-salt dispersion. The perfluordecalin and perfluoractilbromide are contained in the composition of the rapidly excretable perfluororganic compounds at a ratio ranging from 10:1 to 1:10. The mixture of perfluorinated tertiary amines is embodied in the form of the mixture of perfluorotpripropylamine and the co-products thereof: cis- and trans-isomers perfluor-1-propyl 3,4-dimethylpirrolidone and perfluor-1-propyl-4-methhylpiperidine. The inventive method for producing the emulsion includes producing the water-salt dispersion of phospholipids, in homogenizing the perfluororganic compounds therein at a high pressure and in sterilization of the final emulsion. The storage life of the inventive emulsion in the unfrozen state thereof at a temperature of +4° C. is equal to at least 6 months during which the biocompatibility of the emulsion with a biological medium (blood, plasma or serum) is preserved.

摘要翻译： 医药，特别是用于治疗失血，缺氧和缺血状态的药物，用于改善血氧供应和保存分离的灌注器官和组织。 本发明的全氟有机化合物的医用乳液包括快速排泄的全氟有机化合物，例如泛柔比星，全氟化二溴，以全氟化叔胺和磷脂形式的水 - 盐分散体形式的全氟代添加剂。 所述全卢必康素和全氟化磷酰胺以10:1至1:10的比例包含在所述快速排泄的全氟有机化合物的组合物中。 全氟化叔胺的混合物以全氟三丙胺及其副产物的混合物的形式体现：全氟-1-丙基3,4-二甲基吡咯烷酮和全氟-1-丙基-4-甲基哌啶的顺式和反式异构体。 制备乳液的本发明方法包括在高压下均匀化其中的全氟有机化合物并在最终乳液的灭菌中制备磷脂的水 - 盐分散体。 本发明的乳液在+ 4℃的未冷冻状态下的储存寿命等于至少6个月，在此期间乳液与生物介质（血液，血浆或血清）的生物相容性被保留。

公开(公告)号：US20050043572A1

公开(公告)日：2005-02-24

申请号：US10958519

申请日：2004-10-04

申请人： Philip Grosso

发明人： Philip Grosso

IPC分类号： C07C29/124 ,  C07C41/01 ,  C07C19/00

CPC分类号： C07C29/124

摘要： Gas phase hydrocarbons resulting from the operation of offshore petroleum wells are converted into corresponding liquid products which are mixed with liquid phased hydrocarbons resulting from operation of the offshore petroleum well for delivery therewith.

摘要翻译： 由海上石油井运行产生的气相烃转化为相应的液体产物，这些液体产物与由海上石油井的运行产生的液相烃混合，用于输送。

公开(公告)号：US6034290A

公开(公告)日：2000-03-07

申请号：US277094

申请日：1999-03-26

申请人： Mark Andrew Harmer ,  Qun Sun

发明人： Mark Andrew Harmer ,  Qun Sun

IPC分类号： B01J21/08 ,  B01J31/08 ,  B01J31/10 ,  B01J31/16 ,  B01J31/24 ,  B01J31/28 ,  B01J35/10 ,  C07C2/02 ,  C07C5/22 ,  C07C17/358 ,  C07C41/30 ,  C07C45/46 ,  C07C67/04 ,  C07C205/06 ,  C07C17/00 ,  C07C19/00 ,  C07C21/00 ,  C07C21/02

CPC分类号： B01J21/08 ,  B01J31/08 ,  B01J31/10 ,  B01J31/165 ,  B01J31/2419 ,  B01J31/28 ,  B01J31/4007 ,  B01J35/10 ,  C07C17/358 ,  C07C2/02 ,  C07C205/06 ,  C07C41/32 ,  C07C45/46 ,  C07C5/2266 ,  C07C5/2273 ,  C07C5/2562 ,  C07C67/04 ,  B01J2231/10 ,  B01J2231/4205 ,  B01J2231/52 ,  B01J2231/54 ,  B01J2531/16 ,  B01J2531/38 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/847 ,  B01J35/1019 ,  B01J35/1023 ,  B01J35/1038 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1057 ,  B01J35/1061 ,  B01J35/1066 ,  B01J35/1071 ,  B01J35/109 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/12 ,  C07C2523/10 ,  C07C2523/14 ,  C07C2523/26 ,  C07C2523/28 ,  C07C2523/745 ,  C07C2531/08 ,  C07C2531/10 ,  C07C2531/20 ,  C07C2531/26 ,  C07C2531/34 ,  Y02P20/584

摘要： Porous microcomposites comprising a perfluorinated ion-exchange polymer (PFIEP) containing pendant metal cation exchanged sulfonate groups, metal cation exchanged carboxylate groups, or metal cation exchanged sulfonate and carboxylate groups, wherein the metal cation may be ligand coordinated, and optionally pendant sulfonic acid groups, carboxylic acid groups, or sulfonic acid and carboxylic acid groups, the PFIEP being entrapped within and highly dispersed throughout a network of metal oxide, a network of silica or a network of metal oxide and silica can be prepared from PFIEP and one or more precursors selected from the group consisting of a metal oxide precursor, a silica precursor, and a metal oxide and silica precursor using an in situ process. Preferred metal cations are Cr, Sn, Al, Fe, Os, Co, Zn, Hg, Li, Na, Cu, Pd or Ru. Such microcomposites have a first set of pores having a pore size diameter ranging from about 0.5 nm to about 75 nm and may further comprise a second set of pores having a diameter ranging from about 75 nm to about 1000 nm. These microcomposites possess high surface area and exhibit high catalytic activity. The catalyst is used to isomerize 1,4-dichloro-2-butene to 3,4-dichloro-1-butene, a precursor to neoprone.

摘要翻译： 包含含有侧链金属阳离子交换的磺酸盐基团的全氟化离子交换聚合物（PFIEP），金属阳离子交换的羧酸酯基团或金属阳离子交换的磺酸盐和羧酸酯基团的多孔微复合物，其中金属阳离子可以是配体配位的，以及任选的侧链磺酸基团 ，羧酸基团或磺酸和羧酸基团，PFIEP被捕获并高度分散在金属氧化物网络中，二氧化硅网络或金属氧化物和二氧化硅网络可由PFIEP和一种或多种前体 选自由金属氧化物前体，二氧化硅前体和金属氧化物和二氧化硅前体组成的组，其使用原位方法。 优选的金属阳离子是Cr，Sn，Al，Fe，Os，Co，Zn，Hg，Li，Na，Cu，Pd或Ru。 这种微复合材料具有第一组孔径，其孔径范围为约0.5nm至约75nm，并且还可包含直径范围为约75nm至约1000nm的第二组孔。 这些微复合材料具有较高的表面积，具有较高的催化活性。 该催化剂用于将1,4-二氯-2-丁烯异构化为3,4-二氯-1-丁烯，其是新戊酸的前体。