公开(公告)号：US20230295297A1

公开(公告)日：2023-09-21

申请号：US18171291

申请日：2023-02-17

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Fracesca AVOGADRI-CONNORS ,  Helen LAM ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230047941A1

公开(公告)日：2023-02-16

申请号：US17836644

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220315656A1

公开(公告)日：2022-10-06

申请号：US17740100

申请日：2022-05-09

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Patricia CULP ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P37/00 ,  A61P25/28 ,  A61P31/04 ,  A61P25/00 ,  A61P25/08 ,  A61P29/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220251219A1

公开(公告)日：2022-08-11

申请号：US17721112

申请日：2022-04-14

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220185899A1

公开(公告)日：2022-06-16

申请号：US17534291

申请日：2021-11-23

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220162309A1

公开(公告)日：2022-05-26

申请号：US17581471

申请日：2022-01-21

Applicant: Alector LLC

Inventor： Patricia CULP ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Nels P. NIELSON ,  Robert PEJCHAL

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220000083A1

公开(公告)日：2022-01-06

申请号：US17475116

申请日：2021-09-14

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Seung-Joo LEE

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/705

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US20210395361A1

公开(公告)日：2021-12-23

申请号：US17263534

申请日：2019-07-26

Applicant: Alector LLC

Inventor： Patricia CULP ,  Rashmi BANKOTI ,  Helen LAM ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a Siglec-5 protein, e.g., human Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210139581A1

公开(公告)日：2021-05-13

申请号：US16869315

申请日：2020-05-07

Applicant: ALECTOR LLC

Inventor： Patricia CULP ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Nels P. NIELSON ,  Robert PEJCHAL

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190010230A1

公开(公告)日：2019-01-10

申请号：US16138761

申请日：2018-09-21

Applicant: Alector LLC

Inventor： Kate MONROE ,  Tina SCHWABE ,  Francesca AVOGADRI-CONNORS ,  Ilaria TASSI ,  Helen LAM ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.