公开(公告)号：US20200317776A1

公开(公告)日：2020-10-08

申请号：US16835140

申请日：2020-03-30

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190040130A1

公开(公告)日：2019-02-07

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  IIaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230312712A1

公开(公告)日：2023-10-05

申请号：US18174499

申请日：2023-02-24

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  C07K2317/71 ,  C07K2317/90 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2039/505

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220162309A1

公开(公告)日：2022-05-26

申请号：US17581471

申请日：2022-01-21

Applicant: Alector LLC

Inventor： Patricia CULP ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Nels P. NIELSON ,  Robert PEJCHAL

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210139581A1

公开(公告)日：2021-05-13

申请号：US16869315

申请日：2020-05-07

Applicant: ALECTOR LLC

Inventor： Patricia CULP ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Nels P. NIELSON ,  Robert PEJCHAL

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.