公开(公告)号：US06420122B1

公开(公告)日：2002-07-16

申请号：US09405048

申请日：1999-09-27

申请人： David E. Housman ,  Elizabeth A. Preisinger ,  Aleksey G. Kazantsev

发明人： David E. Housman ,  Elizabeth A. Preisinger ,  Aleksey G. Kazantsev

IPC分类号： G01N3353

CPC分类号： G01N33/6896

摘要： Methods of identifying compounds that disrupt aggregation of aggregation-disposed polypeptides, such as huntingtin or beta-amyloid protein, are disclosed. Furthermore, an artificial polypeptide that contains an extended polyglutamine region and DNA that encodes the polypeptide are also disclosed.

摘要翻译： 公开了鉴定破坏凝集排列的多肽（例如亨廷妥或β-淀粉样蛋白）聚集的化合物的方法。 此外，还公开了含有扩展的多聚谷氨酰胺区域的人工多肽和编码多肽的DNA。

公开(公告)号：US6114503A

公开(公告)日：2000-09-05

申请号：US964268

申请日：1997-11-04

申请人： Ying-Fei Wei ,  Steven M. Ruben ,  Aziz Sancar ,  Shiao-Wen D. Hsu ,  Aleksey G. Kazantsev

发明人： Ying-Fei Wei ,  Steven M. Ruben ,  Aziz Sancar ,  Shiao-Wen D. Hsu ,  Aleksey G. Kazantsev

IPC分类号： C12N15/09 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C07K1/00 ,  C12N5/00 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/705 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.