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11.发明授权DNA encoding MAGE-1 C-terminal cytotoxic t lymphocyte immunogenic peptides 失效编码MAGE-1 C末端细胞毒性T淋巴细胞免疫原性肽的DNA
公开(公告)号：US5750395A
公开(公告)日：1998-05-12
申请号：US465167
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/46 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12P21/02 , C12N15/63 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.
摘要翻译： 提供了人MAGE-1抗原的完整核苷酸和氨基酸序列。 来自C末端残基的肽用于定义刺激针对MAGE-1抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。 这些肽特别可用于刺激个体对与黑素瘤相关的MAGE-1抗原的免疫应答的方法。
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公开(公告)号：US20130089596A1
公开(公告)日：2013-04-11
申请号：US13430516
申请日：2012-03-26
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6025 , A61K2039/622 , A61K2039/70 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/16022 , C12N2760/16034
摘要： The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimulatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g., as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.
摘要翻译： 本发明提供了作为多聚体显示物呈递给个体的免疫系统以诱导免疫应答的流感蛋白（例如基质和核蛋白）的组合物。 组合物任选地与包含免疫刺激序列（ISS）的任何类型的免疫调节化合物（IMC）相关联。 本发明还提供可诱导细胞和/或体液免疫应答的流感基因和核蛋白的组合物。 本发明还提供了制备和使用这些组合物例如疫苗用于改善与流感病毒感染相关的症状或降低流感病毒感染风险的方法。
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公开(公告)号：US06464980B1
公开(公告)日：2002-10-15
申请号：US08627820
申请日：1996-04-02
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.
摘要翻译： 提供了人MAGE-1抗原的完整核苷酸和氨基酸序列。 来自C末端残基的肽用于定义刺激针对MAGE-1抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。 这些肽特别可用于刺激个体对与黑素瘤相关的MAGE-1抗原的免疫应答的方法。
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