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1.发明授权DNA encoding MAGE-1 C-terminal cytotoxic t lymphocyte immunogenic peptides 失效编码MAGE-1 C末端细胞毒性T淋巴细胞免疫原性肽的DNA
公开(公告)号：US5750395A
公开(公告)日：1998-05-12
申请号：US465167
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/46 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12P21/02 , C12N15/63 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.
摘要翻译： 提供了人MAGE-1抗原的完整核苷酸和氨基酸序列。 来自C末端残基的肽用于定义刺激针对MAGE-1抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。 这些肽特别可用于刺激个体对与黑素瘤相关的MAGE-1抗原的免疫应答的方法。
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公开(公告)号：US06464980B1
公开(公告)日：2002-10-15
申请号：US08627820
申请日：1996-04-02
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00
摘要： The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the C-terminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.
摘要翻译： 提供了人MAGE-1抗原的完整核苷酸和氨基酸序列。 来自C末端残基的肽用于定义刺激针对MAGE-1抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。 这些肽特别可用于刺激个体对与黑素瘤相关的MAGE-1抗原的免疫应答的方法。
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3.发明授权Peptides of human Papilloma virus for use in human T cell response inducing compositions 失效用于人T细胞应答诱导组合物的人乳头状瘤病毒的肽公开(公告)号：US07364741B1
公开(公告)日：2008-04-29
申请号：US08170344
申请日：1993-05-04
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022
摘要： A peptide comprising an amino acid sequence derived from a human papilloma virus (HPV) protein, wherein said amino acid sequence has the ability to bind to a human Major Histocompatibility Complex Class I molecule. Its use in prophylactic or therapeutic treatment of cervical carcinoma and other HPV-related diseases.
摘要翻译： 一种肽，其包含衍生自人乳头瘤病毒（HPV）蛋白质的氨基酸序列，其中所述氨基酸序列具有结合人类主要组织相容性复合物I类分子的能力。 其用于预防或治疗宫颈癌和其他HPV相关疾病。
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公开(公告)号：US06419931B1
公开(公告)日：2002-07-16
申请号：US08197484
申请日：1994-02-16
IPC分类号： A61K39295
CPC分类号： C07K14/005 , A61K39/00 , C07K14/33 , C07K14/705 , C12N2710/20022 , C12N2730/10122 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222
摘要： Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Cocktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class I restricted coverage.
摘要翻译： 细胞毒性T淋巴细胞反应有效地诱导到感兴趣的抗原，特别是病毒，细菌，寄生虫和肿瘤抗原。 诱导CTL诱导肽的组合物，诱导辅助性T细胞（HTL）应答的佐剂或脂质化肽的组合物刺激抗原特异性CTL应答。 在人类中有效诱导CTL反应的病毒抗原是乙型肝炎的病毒抗原。可以通过两次或更多次加强给药的方案来优化CTL应答。 使用两种或更多种CTL诱导肽的鸡尾酒优化表位和/或MHC I类限制覆盖。
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公开(公告)号：US5679640A
公开(公告)日：1997-10-21
申请号：US400781
申请日：1995-03-08
申请人： Federico C. A. Gaeta , Michael F. Powell , Howard M. Grey , Alessandro D. Sette , Thomas S. Arrhenius
发明人： Federico C. A. Gaeta , Michael F. Powell , Howard M. Grey , Alessandro D. Sette , Thomas S. Arrhenius
CPC分类号： C07K7/08 , C07K14/005 , A61K38/00 , C12N2760/16022
摘要： Peptide compositions are provided which bind MHC molecules of interest and inhibit T cell activation. The peptide compositions of the present invention comprise various isosteres of naturally occurring amino acid sequences. Such compositions may be used to treat diseases associated with particular DR alleles, including autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 提供了结合感兴趣的MHC分子并抑制T细胞活化的肽组合物。 本发明的肽组合物包含天然存在的氨基酸序列的各种等位基因。 这样的组合物可用于治疗与特定DR等位基因相关的疾病，包括自身免疫性疾病如类风湿性关节炎。
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