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公开(公告)号：US20130089596A1
公开(公告)日：2013-04-11
申请号：US13430516
申请日：2012-03-26
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6025 , A61K2039/622 , A61K2039/70 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N2760/16022 , C12N2760/16034
摘要： The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimulatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g., as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.
摘要翻译： 本发明提供了作为多聚体显示物呈递给个体的免疫系统以诱导免疫应答的流感蛋白（例如基质和核蛋白）的组合物。 组合物任选地与包含免疫刺激序列（ISS）的任何类型的免疫调节化合物（IMC）相关联。 本发明还提供可诱导细胞和/或体液免疫应答的流感基因和核蛋白的组合物。 本发明还提供了制备和使用这些组合物例如疫苗用于改善与流感病毒感染相关的症状或降低流感病毒感染风险的方法。
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公开(公告)号：US08740537B2
公开(公告)日：2014-06-03
申请号：US13138714
申请日：2010-04-23
申请人： Michael Reising , Stefan Kempf , Georg Roth
发明人： Michael Reising , Stefan Kempf , Georg Roth
IPC分类号： H01L21/67
CPC分类号： H01L21/67126 , H01L21/6719 , H01L21/67742
摘要： A device for transporting a substrate (5) into a working area (2, 3, 22) which can be temporarily separated in a vacuum-tight manner, and a corresponding method. A transport element (4) transports a substrate (5) in the plane (XY) to a defined working area (2, 3, 22) of a chamber (1). The transport element (4) has a deflectable sealing frame (6) which can be moved in a Z-direction perpendicular with respect to the XY-plane. The sealing frame (6) has two opposing sealing surfaces (10, 11) in the Z-direction. By pressing a closure element (16, 21, 24) against a first sealing surface (10, 11) and thus pressing the second sealing surface (11, 10) against a chamber wall (32, 31), the space of the working area (2, 3, 22) of the chamber (1) can be sealed.
摘要翻译： 一种用于将基板（5）输送到可以以真空密封方式临时分离的工作区域（2,3,22）的装置以及相应的方法。 输送元件（4）将平面（XY）中的基板（5）输送到室（1）的限定的工作区域（2,3,22）。 运输元件（4）具有可偏转的密封框架（6），其可以相对于XY平面垂直于Z方向移动。 密封框架（6）在Z方向上具有两个相对的密封面（10,11）。 通过将闭合元件（16,21,24）压靠在第一密封表面（10,11）上，并且因此将第二密封表面（11,10）压靠在室壁（32,31）上，工作区域的空间 （1）的腔室（2,3,22）可被密封。
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公开(公告)号：US20120027952A1
公开(公告)日：2012-02-02
申请号：US13138714
申请日：2010-04-23
申请人： Michael Reising , Stefan Kempf , Georg Roth
发明人： Michael Reising , Stefan Kempf , Georg Roth
IPC分类号： B65G49/00 , B65G29/00 , C23C16/513 , B65G49/05
CPC分类号： H01L21/67126 , H01L21/6719 , H01L21/67742
摘要： The invention describes a device for transporting a substrate (5) into a working area (2, 3, 22) which can be temporarily separated in a vacuum-tight manner, and a corresponding method. A transport means (4) transports a substrate (5) in the plane (XY) to a defined working area (2, 3, 22) of a chamber (1). The transport means (4) has a deflectable sealing frame (6) which can be moved in a Z-direction perpendicular with respect to the XY-plane. The sealing frame (6) has two opposing sealing surfaces (10, 11) in the Z-direction. By pressing a closure means (16, 21, 24) against a first sealing surface (10, 11) and thus pressing the second sealing surface (11, 10) against a chamber wall (32, 31), the space of the working area (2, 3, 22) of the chamber (1) can be sealed.
摘要翻译： 本发明描述了一种用于将基板（5）输送到可以以真空密封方式临时分离的工作区域（2,3,22）的装置和相应的方法。 传送装置（4）将平面（XY）中的基板（5）传送到室（1）的限定的工作区域（2,3,22）。 传送装置（4）具有可偏转的密封框架（6），其可相对于XY平面垂直于Z方向移动。 密封框架（6）在Z方向上具有两个相对的密封面（10,11）。 通过将闭合装置（16,21,24）压靠在第一密封表面（10,11）上，从而将第二密封表面（11,10）压靠在室壁（32,31）上，工作区域的空间 （1）的腔室（2,3,22）可被密封。
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