公开(公告)号：US20090111102A1

公开(公告)日：2009-04-30

申请号：US12036183

申请日：2008-02-22

申请人： Lauri Diehl ,  Kenneth Flanagan ,  Lian Mo

发明人： Lauri Diehl ,  Kenneth Flanagan ,  Lian Mo

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/6893

摘要： The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.

摘要翻译： 本发明提供了一种通过检测哺乳动物组织或细胞中LY6基因相对于对照而增加的表达来检测胃肠组织或哺乳动物细胞中炎症性肠病的存在的方法。

公开(公告)号：US20070003545A9

公开(公告)日：2007-01-04

申请号：US10886040

申请日：2004-07-08

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： G01N33/53 ,  A61K39/395 ,  C12N5/06 ,  C07K16/44 ,  C07K16/18

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

公开(公告)号：US20060183169A1

公开(公告)日：2006-08-17

申请号：US11407991

申请日：2006-04-21

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： G01N33/574 ,  C12N5/06 ,  C07K16/30

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24 ,  Y02A50/54

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

公开(公告)号：US20050100544A1

公开(公告)日：2005-05-12

申请号：US10886040

申请日：2004-07-08

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/44 ,  C12N5/06 ,  G01N33/53

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24 ,  Y02A50/54

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

摘要翻译： 本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文进一步提供了治疗和诊断炎性疾病的方法。