公开(公告)号：US20070003545A9

公开(公告)日：2007-01-04

申请号：US10886040

申请日：2004-07-08

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： G01N33/53 ,  A61K39/395 ,  C12N5/06 ,  C07K16/44 ,  C07K16/18

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

公开(公告)号：US20060183169A1

公开(公告)日：2006-08-17

申请号：US11407991

申请日：2006-04-21

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： G01N33/574 ,  C12N5/06 ,  C07K16/30

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24 ,  Y02A50/54

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

公开(公告)号：US20050100544A1

公开(公告)日：2005-05-12

申请号：US10886040

申请日：2004-07-08

申请人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

发明人： Dan Eaton ,  Maria Pisabarro ,  Kerstin Schmidt ,  Richard Vandlen ,  Nancy Chiang ,  Lauri Diehl

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/44 ,  C12N5/06 ,  G01N33/53

CPC分类号： G01N33/57449 ,  C07K14/5421 ,  C07K16/24 ,  C07K2317/76 ,  G01N33/57415 ,  G01N33/57442 ,  G01N33/57496 ,  G01N33/576 ,  G01N33/6869 ,  G01N2333/715 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/24 ,  Y02A50/54

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

摘要翻译： 本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文进一步提供了治疗和诊断炎性疾病的方法。

公开(公告)号：US20050019325A1

公开(公告)日：2005-01-27

申请号：US10921710

申请日：2004-08-18

申请人： Paul Carter ,  Nancy Chiang ,  Kyung Kim ,  William Matthews ,  Maria Rodrigues

发明人： Paul Carter ,  Nancy Chiang ,  Kyung Kim ,  William Matthews ,  Maria Rodrigues

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K14/72 ,  A61K39/395 ,  C07K16/28 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/6863 ,  A61K38/00 ,  C07K14/715 ,  C07K14/72 ,  C07K14/721 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/042

摘要： The WSX receptor and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed, including various uses therefor. Uses for WSX ligands (e.g., anti-WSX receptor agonist antibodies or OB protein) in hematopoiesis are also disclosed.

摘要翻译： 公开了与其结合的WSX受体和抗体（包括激动剂和中和抗体），包括其各种用途。 还公开了在造血作用中用于WSX配体（例如抗WSX受体激动剂抗体或OB蛋白）。

公开(公告)号：US20060280737A1

公开(公告)日：2006-12-14

申请号：US11439325

申请日：2006-05-22

申请人： Paul Carter ,  Nancy Chiang ,  Kyung Kim ,  William Matthews ,  Maria Rodrigues

发明人： Paul Carter ,  Nancy Chiang ,  Kyung Kim ,  William Matthews ,  Maria Rodrigues

IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C07K16/28

CPC分类号： G01N33/6863 ,  A61K38/00 ,  C07K14/715 ,  C07K14/72 ,  C07K14/721 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/042

摘要： Methods for identifying antibodies that decrease body weight, fat depot weight or food intake in an obese animal are provided, as well as antibodies. Preferred antibodies bind to a reactor having a WSX motif and the extracellular domain sequence within SEQ ID NO:2.