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公开(公告)号：US20070025962A1
公开(公告)日：2007-02-01
申请号：US11528596
申请日：2006-09-28
申请人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
发明人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
IPC分类号： A61K38/20 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/04 , C12N5/06 , C07K14/54 , C07K16/24
CPC分类号： C07K14/52 , C07K14/47 , C07K14/5421 , C07K14/705 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N33/6869 , G01N33/6893
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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2.发明申请Composition Comprising and Method of Using Angiopoietin-Like Protein 3 ANGPTL3 审中-公开使用促生长素样蛋白3的组合物和方法ANGPTL3公开(公告)号：US20070134250A1
公开(公告)日：2007-06-14
申请号：US11537567
申请日：2006-09-29
IPC分类号： A61K39/395 , C12Q1/68 , A61K38/55
CPC分类号： C07K14/515 , A61K48/00 , C12N2799/022
摘要： The present invention is directed to methods and means for making and using Angpt13 polypeptides. The invention specifically concerns the use of Angpt13 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angpt13 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明具体涉及Angpt13多肽在诱导肝脏再生和血管生成中的应用。 其他方法包括在诊断和治疗肝脏疾病中使用Angpt13多肽。 本文还提供结合本发明多肽的抗体。
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公开(公告)号：US20060019307A1
公开(公告)日：2006-01-26
申请号：US10795482
申请日：2004-03-09
申请人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
发明人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
CPC分类号： C07K14/52 , C07K14/47 , C07K14/5421 , C07K14/705 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N33/6869 , G01N33/6893
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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公开(公告)号：US20070003545A9
公开(公告)日：2007-01-04
申请号：US10886040
申请日：2004-07-08
申请人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
发明人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
IPC分类号： G01N33/53 , A61K39/395 , C12N5/06 , C07K16/44 , C07K16/18
CPC分类号： G01N33/57449 , C07K14/5421 , C07K16/24 , C07K2317/76 , G01N33/57415 , G01N33/57442 , G01N33/57496 , G01N33/576 , G01N33/6869 , G01N2333/715 , G01N2800/08 , G01N2800/085 , G01N2800/24
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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公开(公告)号：US20060210991A1
公开(公告)日：2006-09-21
申请号：US10795503
申请日：2004-03-09
申请人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
发明人： Dan Eaton , Dorothy French , J. Grimaldi , Kenneth Hillan , Maria Pisabarro , Kerstin Schmidt , Victoria Smith , Daniel Tumas , Richard Vandlen , Colin Watanabe , P. Williams , William Wood
CPC分类号： C07K14/52 , C07K14/47 , C07K14/5421 , C07K14/705 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N33/6869 , G01N33/6893
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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公开(公告)号：US20060183169A1
公开(公告)日：2006-08-17
申请号：US11407991
申请日：2006-04-21
申请人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
发明人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
IPC分类号： G01N33/574 , C12N5/06 , C07K16/30
CPC分类号： G01N33/57449 , C07K14/5421 , C07K16/24 , C07K2317/76 , G01N33/57415 , G01N33/57442 , G01N33/57496 , G01N33/576 , G01N33/6869 , G01N2333/715 , G01N2800/08 , G01N2800/085 , G01N2800/24 , Y02A50/54
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
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公开(公告)号：US20050100544A1
公开(公告)日：2005-05-12
申请号：US10886040
申请日：2004-07-08
申请人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
发明人： Dan Eaton , Maria Pisabarro , Kerstin Schmidt , Richard Vandlen , Nancy Chiang , Lauri Diehl
IPC分类号： A61K39/395 , C07K16/18 , C07K16/44 , C12N5/06 , G01N33/53
CPC分类号： G01N33/57449 , C07K14/5421 , C07K16/24 , C07K2317/76 , G01N33/57415 , G01N33/57442 , G01N33/57496 , G01N33/576 , G01N33/6869 , G01N2333/715 , G01N2800/08 , G01N2800/085 , G01N2800/24 , Y02A50/54
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译： 本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文进一步提供了治疗和诊断炎性疾病的方法。
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