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70 条记录 (耗时 0.037 秒)

    Substituted pyrido (1,2-c)imidazo(1,2-a)benzimidazoles, processes for their preparation, their use and pharmaceutical preparations based on these compounds
    11.
    发明授权
    Substituted pyrido (1,2-c)imidazo(1,2-a)benzimidazoles, processes for their preparation, their use and pharmaceutical preparations based on these compounds 失效
    取代的吡啶（1,2-c）咪唑并（1,2-a）苯并咪唑，其制备方法及其用途和基于这些化合物的药物制剂

    公开(公告)号：US4585775A

    公开(公告)日：1986-04-29

    申请号：US650106

    申请日：1984-09-13

    申请人： Volker Hitzel ,  Gerhard Rackur ,  Martin Bickel

    发明人： Volker Hitzel ,  Gerhard Rackur ,  Martin Bickel

    IPC分类号： C07D471/10 ,  A61K31/435 ,  A61P1/04 ,  C07D213/38 ,  C07D213/53 ,  C07D401/06 ,  C07D471/14 ,  A61K31/44 ,  C07D471/12

    CPC分类号： C07D213/53 ,  C07D213/38 ,  C07D401/06 ,  C07D471/14 ,  Y02P20/55

    摘要： The invention relates to compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are hydrogen, alkyl, trifluoromethyl, halogen, alkoxycarbonyl, alkoxy or alkanoyl, R.sup.3, R.sup.4 and R.sup.5 are identical or different and are hydrogen, methyl, alkoxy or alkoxyethoxy, and R is hydrogen or a group SR.sup.6, in which R.sup.6 is the lone, unpaired electron of the 12-sulfenyl radical, hydrogen, optionally substituted alkyl, alkenyl, alkynyl, alkanoyl, optionally mono- or poly-substituted benzoyl, fuoryl, phenacyl, phenoxyacetyl, phenylacetyl or another conventional thiol-protective group, and to physiologically acceptable salts thereof, and to processes for their preparation, to their use as a gastric acid secretion inhibitor and to pharmaceutical preparations based on these compounds.

    摘要翻译： 本发明涉及式（I）的化合物，其中R 1和R 2相同或不同，为氢，烷基，三氟甲基，卤素，烷氧基羰基，烷氧基或烷酰基，R 3，R 4和R 5相同或不同， 氢，甲基，烷氧基或烷氧基乙氧基，R是氢或基团SR6，其中R6是12-亚磺酰基的单体不成对电子，氢，任选取代的烷基，烯基，炔基，烷酰基，任选单或多 取代苯甲酰基，富酰基，苯甲酰甲基，苯氧基乙酰基，苯乙酰基或另一种常规硫醇保护基，及其生理上可接受的盐，及其制备方法，用作胃酸分泌抑制剂和基于这些化合物的药物制剂 。

    Use of C2-substituted indan-1-ol systems for preparing medicaments for the prophylaxis or treatment of obesity
    14.
    发明授权
    Use of C2-substituted indan-1-ol systems for preparing medicaments for the prophylaxis or treatment of obesity 有权
    使用C2取代的茚满-1-醇系统制备用于预防或治疗肥胖症的药物

    公开(公告)号：US07763662B2

    公开(公告)日：2010-07-27

    申请号：US11006164

    申请日：2004-12-07

    申请人： Gerhard Jaehne ,  Volker Krone ,  Martin Bickel ,  Matthias Gossel

    发明人： Gerhard Jaehne ,  Volker Krone ,  Martin Bickel ,  Matthias Gossel

    IPC分类号： A61K31/10

    CPC分类号： A61K31/255

    摘要： Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of C2-substituted indan-1-ol systems and their physiologically acceptable salts and physiologically functional derivatives. Compounds for use in the methods of the embodiments of the invention include compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts.

    摘要翻译： 本发明的实施方案涉及减轻哺乳动物体重和用于预防或治疗肥胖症的方法，其包括施用C 2-取代的茚满-1-醇体系及其生理学上可接受的盐和生理功能衍生物。 用于本发明实施方案的方法的化合物包括其中基团如所定义的式（I）化合物及其生理学上可接受的盐。