公开(公告)号：US4961476A

公开(公告)日：1990-10-09

申请号：US330762

申请日：1989-03-30

Applicant: Lothar Witte ,  Norbert Stelter ,  Ulrich Appt ,  Rolf Geiger ,  Klaus-Gerhard Wolpert ,  Stephan Lawitzki

Inventor： Lothar Witte ,  Norbert Stelter ,  Ulrich Appt ,  Rolf Geiger ,  Klaus-Gerhard Wolpert ,  Stephan Lawitzki

IPC: B60K17/35 ,  B60K23/08 ,  B60T8/1761 ,  B60T8/1769 ,  F16D48/12

CPC classification number: B60K23/0808

Abstract: The arrangement controls a friction element for limiting a rotational speed compensation between the axles of a two-axle or all-wheel-driven vehicle as a function of the difference of the medium wheel speeds of both axles (longitudinal speed difference). This longitudinal speed difference is compared with two driving-speed-dependent tolerance bands, the first tolerance band being determining for positive and the second tolerance band being determining for negative longitudinal speed differences. If the values of the longitudinal speed differences are above the first or below the second tolerance band, the limiting is increased; if the values are within the tolerance bands, the instantaneous limiting is maintained; and if the values are between the tolerance bands, the limiting is reduced. This arrangement may also be expanded to include an adaptation device of the limit criteria with respect to different tread radii of the wheels and a cornering correction device.

Abstract translation: 该布置控制用于限制两轴或全轮驱动车辆的轴之间的转速补偿的摩擦元件，作为两轴的中轮速度差（纵向速度差）的函数。 将该纵向速度差与两个驱动速度相关的公差带进行比较，第一公差带被确定为正，第二公差带是确定负的纵向速度差。 如果纵向速度差的值高于第一或低于第二公差带，则限制增加; 如果值在公差带内，则保持瞬时限制; 并且如果这些值在公差带之间，则限制被减小。 该布置还可以扩展到包括相对于车轮的不同胎面半径和转弯校正装置的极限标准的适配装置。

公开(公告)号：US4879403A

公开(公告)日：1989-11-07

申请号：US267753

申请日：1988-11-02

Applicant: Volker Teetz ,  Rolf Geiger ,  Hansjorg Urbach ,  Reinhard Becker ,  Bernward Scholkens

Inventor： Volker Teetz ,  Rolf Geiger ,  Hansjorg Urbach ,  Reinhard Becker ,  Bernward Scholkens

IPC: C07C227/08 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07C227/10 ,  C07C227/16 ,  C07C229/36 ,  C07C237/06 ,  C07D209/52 ,  C07D451/04 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07K5/0222 ,  C07D209/52 ,  A61K38/00

Abstract: Compounds of the formula I ##STR1## in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R.sup.1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring .alpha.-aminoacid, which may be protected, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.

Abstract translation: 其中碳原子3上的羧基相对于顺式构型的双环体系位于内部位置的式I（I）化合物，其中R 1表示氢，烯丙基，乙烯基或 可以被保护的天然存在的α-氨基酸的侧链，R2表示氢，烷基，烯基或芳烷基，Y表示氢或羟基，Z表示氢，或Y和Z表示氧，X表示烷基，烯基 或环烷基，或任选被烷基，烷氧基，羟基，卤素，硝基，氨基，烷基氨基，二烷基氨基或亚甲二氧基单，二或三取代的芳基，或表示吲哚-3-基，其制备方法， 含有这些化合物的药剂及其用途。

公开(公告)号：US4639333A

公开(公告)日：1987-01-27

申请号：US659865

申请日：1984-10-12

Applicant: Rainer Obermeier ,  Rolf Geiger ,  Ulrich Grau

Inventor： Rainer Obermeier ,  Rolf Geiger ,  Ulrich Grau

IPC: C12P21/02 ,  C07K14/62 ,  C07K7/40

CPC classification number: C07K14/62 ,  Y02P20/55 ,  Y10S930/26

Abstract: The invention relates to a process for the preparation of insulins from analogs of preproinsulins, which comprises reacting preproinsulin analogs, at a pH below the isoelectric point of the insulins in the presence of trypsin or a trypsin-like endopeptidase, with an ester of natural amino acids or their derivatives and then cleaving off the ester group and other protective groups which may optionally be present.

Abstract translation: 本发明涉及从前胰岛素类似物制备胰岛素的方法，其包括在胰蛋白酶或胰蛋白酶样内肽酶存在下，将胰岛素类似物与胰岛素类胰蛋白酶存在下的pH低于胰岛素的等电点与天然氨基酸的酯反应 酸或其衍生物，然后断开酯基和可任选存在的其它保护基。

公开(公告)号：US4621073A

公开(公告)日：1986-11-04

申请号：US575703

申请日：1984-01-31

Applicant: Axel Friedrich ,  Wolfgang Konig ,  Volker Teetz ,  Rolf Geiger ,  Jurgen K. Sandow

Inventor： Axel Friedrich ,  Wolfgang Konig ,  Volker Teetz ,  Rolf Geiger ,  Jurgen K. Sandow

IPC: C07K7/64 ,  A61K38/00 ,  A61K38/04 ,  A61P5/00 ,  A61P5/02 ,  C07C231/00 ,  C07K1/113 ,  C07K7/06 ,  C07K14/575 ,  C07K14/655 ,  A61K37/24 ,  C07K7/26

CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

Abstract: The invention relates to cyclic hexapeptides of the general formula III ##STR1## in which X represents the radical of an L-aminoacid of the general formula IIIa ##STR2## in which A and B are identical or different and denote alkyl having 1 to 3 carbon atoms, or A and B together represent a saturated, unsaturated or aromatic monocyclic or bicyclic structure having 3 to 6 carbon atoms, n denotes 0 or 1, and Y represents an aliphatic or aromatic L-aminoacid the side chain of which can be hydroxylated, and their salts with physiologically tolerated acids, and to a process for their preparation and their use and their intermediates.

Abstract translation: 本发明涉及通式III“IMAGE”的环状六肽，其中X表示通式IIIa（IIIa）的L-氨基酸的基团，其中A和B相同或不同，表示具有1 至3个碳原子，或A和B一起表示具有3至6个碳原子的饱和，不饱和或芳族单环或双环结构，n表示0或1，Y表示脂族或芳族L-氨基酸，其侧链可以 羟基化，以及它们与生理上耐受的酸的盐，以及它们的制备方法及其用途及其中间体。

公开(公告)号：US4457866A

公开(公告)日：1984-07-03

申请号：US435610

申请日：1982-10-19

Applicant: Hermann E. Karges ,  Helmut Heber ,  Rainer Uhmann ,  Volker Teetz ,  Rolf Geiger

Inventor： Hermann E. Karges ,  Helmut Heber ,  Rainer Uhmann ,  Volker Teetz ,  Rolf Geiger

IPC: E04F15/02 ,  C07K5/04 ,  C07K5/062 ,  C07K5/072 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K7/06 ,  C12Q1/37 ,  C07C103/52 ,  C12Q1/00

CPC classification number: C07K7/06 ,  C07K5/06026 ,  C07K5/06052 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06095 ,  C07K5/06104 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1013 ,  C07K5/1016 ,  C12Q1/37 ,  C12Q2337/12 ,  Y10S530/802 ,  Y10S930/28

Abstract: What are disclosed are chromogenic peptides useful as substrates for the detection and determination of enzymes having a hydrolytic action and methods for detecting and determining enzymes with such peptides.

Abstract translation: 所公开的是可用作检测和测定具有水解作用的酶的底物的显色肽以及用这些肽检测和测定酶的方法。

公开(公告)号：US4302448A

公开(公告)日：1981-11-24

申请号：US158595

申请日：1980-06-11

Applicant: Martin Bickel ,  Rolf Geiger ,  Richard Leeb ,  Walter Petri

Inventor： Martin Bickel ,  Rolf Geiger ,  Richard Leeb ,  Walter Petri

IPC: A61K9/00 ,  A61K9/20 ,  A61K38/22 ,  A61K37/00

CPC classification number: A61K9/0019 ,  A61K38/2235 ,  A61K9/2004

Abstract: What are disclosed are secretin preparations with an intensified and protracted action, especially subcutaneously and rectally administrable preparations containing phenolic depot bodies. A process for the manufacture of the preparations and their use as well as phenolic depot bodies and the manufacture thereof are described.

Abstract translation: 所公开的是具有强化和延长作用的促胰液制剂，特别是含有酚类贮库体的皮下和直肠给药制剂。 描述了制备其制备方法及其用途以及酚类贮库体及其制造方法。

公开(公告)号：US4003884A

公开(公告)日：1977-01-18

申请号：US578196

申请日：1975-05-16

Applicant: Wolfgang Konig ,  Rolf Geiger ,  Jurgen K. Sandow

Inventor： Wolfgang Konig ,  Rolf Geiger ,  Jurgen K. Sandow

IPC: A61K38/04 ,  A61K38/00 ,  C07K7/23 ,  C07K14/575 ,  C07C103/52 ,  A61K37/00

CPC classification number: C07K7/23 ,  A61K38/00 ,  Y10S514/80 ,  Y10S930/13

Abstract: Peptides having LH-RH/FSH-RH activity useful for treatment of male and female sterility.

Abstract translation: 具有LH-RH / FSH-RH活性的肽可用于治疗男性和女性不育症。

公开(公告)号：US5747504A

公开(公告)日：1998-05-05

申请号：US709286

申请日：1996-09-06

Applicant: Rainer Henning ,  Hansjorg Urbach ,  Volker Teetz ,  Rolf Geiger ,  Bernward Scholkens

Inventor： Rainer Henning ,  Hansjorg Urbach ,  Volker Teetz ,  Rolf Geiger ,  Bernward Scholkens

IPC: A61K38/00 ,  A61K38/55 ,  C07K5/02 ,  A61K31/47

CPC classification number: C07K5/0222 ,  A61K38/556

Abstract: The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

公开(公告)号：US5401766A

公开(公告)日：1995-03-28

申请号：US208443

申请日：1994-03-09

Applicant: Rolf Geiger ,  Volker Teetz ,  Hansjorg Urbach ,  Bernward Scholkens ,  Rainer Henning

Inventor： Rolf Geiger ,  Volker Teetz ,  Hansjorg Urbach ,  Bernward Scholkens ,  Rainer Henning

IPC: A61K38/00 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61P9/12 ,  C07D209/42 ,  C07D217/26 ,  C07D233/64 ,  C07D241/20 ,  C07D307/54 ,  C07D309/10 ,  C07D317/66 ,  C07D333/24 ,  C07D335/02 ,  C07D339/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07D209/34 ,  A61K31/405

CPC classification number: C07K5/0222 ,  C07D217/26 ,  A61K38/00

Abstract: Aminoacid derivatives of the formula I ##STR1## A , n, R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these compounds, and their use as medicaments.

Abstract translation: 式I的氨基酸衍生物A，n，R 1，R 2和R 3具有给定的含义及其盐，其制备方法，基于这些化合物的药物制剂及其作为药物的用途。

公开(公告)号：US5162362A

公开(公告)日：1992-11-10

申请号：US565887

申请日：1983-12-27

Applicant: Rolf Geiger ,  Volker Teetz ,  Hansjorg Urbach ,  Bernward Scholkens ,  Rainer Henning

Inventor： Rolf Geiger ,  Volker Teetz ,  Hansjorg Urbach ,  Bernward Scholkens ,  Rainer Henning

IPC: A61K38/00 ,  C07D217/26 ,  C07K5/02

CPC classification number: C07K5/0222 ,  C07D217/26 ,  A61K38/00

Abstract: What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.

Abstract translation: 所公开的是下式的氨基酸化合物，其中n为0或1，及其盐，所述化合物和具有降血压性质的盐; 制备化合物的方法; 含有该化合物或盐的药物组合物; 以及使用化合物和盐治疗高血压。