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11.发明申请BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的双相异构尿素，硫脲，胍和氰基化合物公开(公告)号：US20160355517A1
公开(公告)日：2016-12-08
申请号：US14442503
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC.
Inventor： Shelley Allen , Barbara J. Brandhuber , Kevin Ronald Condroski , Lily Huang , Timothy Kercher , Shannon L. Winski
IPC: C07D487/04 , C07D519/00 , C07D403/12 , C07D471/04
CPC classification number: C07D487/04 , C07D231/56 , C07D403/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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公开(公告)号：US08987251B2
公开(公告)日：2015-03-24
申请号：US14057882
申请日：2013-10-18
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Hicks , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC: A61K31/437 , C07D471/04 , C07D451/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/437 , C07D451/06 , C07D519/00
Abstract: Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification.
Abstract translation: 本文提供了一种在哺乳动物中治疗PIM-1和/或PIM-3和/或PIM-3激酶介导的病症的方法，其包括向所述哺乳动物施用治疗有效量的式I化合物：其中 A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有说明书中给出的含义。
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公开(公告)号：US20140045835A1
公开(公告)日：2014-02-13
申请号：US14054459
申请日：2013-10-15
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Robert Kirk DeLisle , Julie Marie Hicks , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein are methods of treating diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases by administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula I: in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification.
Abstract translation: 本文提供了通过向有需要的哺乳动物施用治疗有效量的式I化合物来治疗由PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病的方法：其中B，R1， R1a，R2，R3，R4，R5，R6，R7，R10和R11具有说明书中给出的含义。
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公开(公告)号：US20230357277A1
公开(公告)日：2023-11-09
申请号：US18027300
申请日：2021-09-21
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Matthew Arnold Marx , Shelley Allen , Mark Joseph Chicarelli , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Michael Christopher Hilton , Dean Russell Kahn , Macedonio Junior Mejia , Phong Nguyen , Spencer Pajk , Martha E. Rodriguez , Pavel Yu Savechenkov , Tony Pisal Tang
IPC: C07D519/00 , A61P35/00
CPC classification number: C07D519/00 , A61P35/00
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：US20230339976A1
公开(公告)日：2023-10-26
申请号：US18020013
申请日：2021-08-03
Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
Inventor： Xiaolun Wang , Matthew Arnold Marx , John David Lawson , Shelley Allen , Patrick Michael Barbour , James Francis Blake , Joshua Ryan Dahlke , Donghua Dai , Jay Bradford Fell , John Peter Fischer , Sherif Hosam Hassanien , Michael Christopher Hilton , Macedonio Junior Mejia , Jacob Matthew O’Leary , Tony Pisal Tang
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D519/00 , C07D471/04
Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
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Patent Agency Ranking
16.发明授权公开(公告)号：US10889589B2
公开(公告)日：2021-01-12
申请号：US16415575
申请日：2019-05-17
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC: C07D401/14 , C07D405/14 , C07D403/14 , C07D491/048 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D405/12 , C07D413/12 , C07D453/02 , C07D231/52 , C07D231/56 , C07D401/04 , C07D409/14 , C07D471/08
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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17.发明授权公开(公告)号：US09896435B2
公开(公告)日：2018-02-20
申请号：US14442613
申请日：2013-11-12
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Barbara J. Brandhuber , Timothy Kercher , Gabrielle R. Kolakowski , Shannon L. Winski
IPC: C07D401/14 , C07D403/12 , C07D403/14
CPC classification number: C07D401/14 , A61P29/00 , A61P35/00 , C07D403/12 , C07D403/14
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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![Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors](/abs-image/US/2017/10/24/US09796724B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796724B2
公开(公告)日：2017-10-24
申请号：US15401895
申请日：2017-01-09
Applicant: Array BioPharma, Inc.
Inventor： Shelley Allen , Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC: A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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19.发明授权公开(公告)号：US09790178B2
公开(公告)日：2017-10-17
申请号：US14442514
申请日：2013-11-13
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Yutong Jiang , Timothy Kercher , Shannon L. Winski
IPC: C07D491/02 , C07D487/00 , A61K31/50 , A61K31/519 , A61K31/44 , C07D207/50 , C07D403/12 , C07D471/04 , C07D487/04 , C07D207/14 , C07D513/04 , C07C53/18
CPC classification number: C07D207/50 , C07C53/18 , C07D207/14 , C07D403/12 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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20.发明申请N-PYRROLIDINYL,N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 有权作为TRKA激酶抑制剂的N-吡咯烷酮，N' - 吡唑并 - 尿素，硫脲，胍和氰基胍化合物公开(公告)号：US20160280682A1
公开(公告)日：2016-09-29
申请号：US14442613
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC.
Inventor： Shelley Allen , Barbara J. Brandhuber , Timothy Kercher , Gabrielle R. Kolakowski , Shannon L. Winski
IPC: C07D401/14 , C07D403/12 , C07D403/14
CPC classification number: C07D401/14 , A61P29/00 , A61P35/00 , C07D403/12 , C07D403/14
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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