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公开(公告)号：US20120045443A1
公开(公告)日：2012-02-23
申请号：US13198979
申请日：2011-08-05
IPC分类号： A61K39/395 , C12N15/13 , A61P25/28 , A61P25/00 , C12N5/10 , A61K31/7088 , C12N15/63 , C12N5/16 , C12N5/0793 , C12N1/21 , C07K16/28 , A61P25/02
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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12.发明授权Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same 有权通过施用神经生长因子拮抗剂和NSAID治疗疼痛的方法和含有它们的组合物公开(公告)号：US08034346B2
公开(公告)日：2011-10-11
申请号：US12644087
申请日：2009-12-22
IPC分类号： A61K39/395 , C07K16/22 , C12P21/06
CPC分类号： C07K16/22 , A61K31/192 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/76 , A61K2300/00
摘要： The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.
摘要翻译： 本发明的特征在于治疗或预防疼痛的方法，包括给予一定量的神经生长因子拮抗剂（例如抗NGF抗体）和一定量的NSAID，使得它们一起提供有效的疼痛缓解。 本发明还特征在于包含神经生长因子拮抗剂和NSAID的组合物以及含有其的试剂盒。
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13.发明授权Methods for treating bone cancer pain by administering a nerve growth factor antagonist antibody 有权通过施用神经生长因子拮抗剂抗体治疗骨癌疼痛的方法公开(公告)号：US08007800B2
公开(公告)日：2011-08-30
申请号：US12404759
申请日：2009-03-16
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
摘要翻译： 本发明的特征在于通过施用神经生长因子（NGF）拮抗剂来预防或治疗包括与骨转移相关的癌症疼痛的骨癌疼痛的方法和组合物。 NGF拮抗剂可以是能够结合hNGF的抗NGF（例如抗hNGF）抗体。
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14.发明授权Methods for treating pain by administering a nerve growth factor antagonist and an NSAID 失效通过施用神经生长因子拮抗剂和NSAID治疗疼痛的方法公开(公告)号：US07655231B2
公开(公告)日：2010-02-02
申请号：US10783730
申请日：2004-02-19
IPC分类号： A61K39/395 , C07K16/22 , C12P21/06
CPC分类号： C07K16/22 , A61K31/192 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/76 , A61K2300/00
摘要： The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.
摘要翻译： 本发明的特征在于治疗或预防疼痛的方法，包括给予一定量的神经生长因子拮抗剂（例如抗NGF抗体）和一定量的NSAID，使得它们一起提供有效的疼痛缓解。 本发明还特征在于包含神经生长因子拮抗剂和NSAID的组合物以及含有其的试剂盒。
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公开(公告)号：US20100003261A1
公开(公告)日：2010-01-07
申请号：US12478501
申请日：2009-06-04
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention andior treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和治疗细胞变性中的应用，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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公开(公告)号：US6153189A
公开(公告)日：2000-11-28
申请号：US156923
申请日：1998-09-18
申请人： Leonard G. Presta , David L. Shelton , Roman Ufer
发明人： Leonard G. Presta , David L. Shelton , Roman Ufer
IPC分类号： G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号： C07K19/00 , C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
摘要翻译： 本发明涉及人trkB和trkC受体及其功能衍生物。 本发明还涉及包含与免疫球蛋白序列融合的trk受体序列的免疫粘附素。
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17.发明授权Methods for treating bone cancer by administering a nerve growth factor antagonist antibody 有权通过施用神经生长因子拮抗剂抗体治疗骨癌的方法公开(公告)号：US08557245B2
公开(公告)日：2013-10-15
申请号：US13517506
申请日：2012-06-13
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
摘要翻译： 本发明的特征在于通过施用神经生长因子（NGF）拮抗剂来预防或治疗包括与骨转移相关的癌症疼痛的骨癌疼痛的方法和组合物。 NGF拮抗剂可以是能够结合hNGF的抗NGF（例如抗hNGF）抗体。
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18.发明授权Methods for treating bone cancer by administering a nerve growth factor antagonist antibody 有权通过施用神经生长因子拮抗剂抗体治疗骨癌的方法公开(公告)号：US08226951B2
公开(公告)日：2012-07-24
申请号：US13153587
申请日：2011-06-06
IPC分类号： A61K39/395 , C07K16/22 , C12P21/08
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
摘要翻译： 本发明的特征在于通过施用神经生长因子（NGF）拮抗剂来预防或治疗包括与骨转移相关的癌症疼痛的骨癌疼痛的方法和组合物。 NGF拮抗剂可以是能够结合hNGF的抗NGF（例如抗hNGF）抗体。
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公开(公告)号：US20110268725A1
公开(公告)日：2011-11-03
申请号：US13090048
申请日：2011-04-19
申请人： David L. Shelton
发明人： David L. Shelton
CPC分类号： C07K16/22 , A61K31/573 , A61K39/3955 , A61K39/39566 , A61K2039/505 , A61K2039/507 , C07K16/241 , C07K16/4291 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates generally to methods of using anti-NGF antibodies in the treatment of various NGF-related disorders, including asthma, arthritis and psoriasis. The methods are effective in treating these disorder in a patient without having a significant adverse effect on the immune system of the patient.
摘要翻译： 本发明一般涉及使用抗NGF抗体治疗各种NGF相关疾病（包括哮喘，关节炎和牛皮癣）的方法。 所述方法在治疗患者的这些疾病中是有效的，而不会对患者的免疫系统产生显着的不利影响。
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公开(公告)号：US07985413B2
公开(公告)日：2011-07-26
申请号：US12398260
申请日：2009-03-05
IPC分类号： A01N25/12
CPC分类号： C02F1/50 , C02F1/76 , C02F1/766 , C02F2303/20
摘要： Microbiological control is achieved by continuously and inexpensively dosing water in contact with biofilm, or that comes into contact with biofilm, using a highly effective biocide that provides very effective microbiocidal control of planktonic microorganisms and of biofilm species, even where the biofilm infestations have been in existence for long periods of time and thus have encased themselves in a substantial quantity of slimy defensive polysaccharide layers or films. In addition, the biocide used makes possible significant reduction in copper and/or iron surfaces in contact with the water as compared to N,N′-bromochloro-5,5-dimethyl hydantoin. Still other advantages are made possible by the described technology.
摘要翻译： 微生物控制是通过使用高效杀生物剂连续低成本地接触生物膜或与生物膜接触的水来实现的，即使在生物膜侵袭已经进入生物膜的情况下，也能提供对浮游微生物和生物膜物种的非常有效的杀微生物控制 存在很长一段时间，因此已经包含了大量的防粘多糖层或薄膜。 此外，与N，N'-溴氯-5,5-二甲基乙内酰脲相比，所用的杀生物剂使得与水接触的铜和/或铁表面可能显着减少。 所描述的技术还有其他优点。
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