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公开(公告)号：US08399647B2
公开(公告)日：2013-03-19
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US07960515B2
公开(公告)日：2011-06-14
申请号：US12332944
申请日：2008-12-11
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20100330078A1
公开(公告)日：2010-12-30
申请号：US12365638
申请日：2009-02-04
申请人： STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
发明人： STEVEN L. BENDER , GERALD F. CASPERSON , DANA D. HU-LOWE , XIN JIANG , GANG LI , MICHAEL A. NORTH , JIANYING WANG , GRANT WICKMAN , PETER BRAMS , HAICHUN HUANG , BRIGITTE DEVAUX , HAIBIN CHEN , DAWN M. TANAMACHI , KRISTOPHER TOY , LAN YANG , TIM W. SPROUL , MARK YAMANAKA
IPC分类号： A61K39/395 , C07K16/28 , C07K16/00 , A61P35/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US07384632B2
公开(公告)日：2008-06-10
申请号：US10312316
申请日：2001-06-22
IPC分类号： A61K39/00 , A61K39/395 , C12P21/08
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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公开(公告)号：US20050036942A1
公开(公告)日：2005-02-17
申请号：US10937046
申请日：2004-09-08
IPC分类号： C07K14/47 , C07K14/705 , C07K16/18 , A61K51/00 , A61K39/395
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/77 , C07K2319/00
摘要： The invention provides antibodies targeted at a tumor antigen prevalent on prostate tumors and methods useful in alleviating cancers expressing the antigen, as well as nucleic acids and cells for expressing the antibodies.
摘要翻译： 本发明提供靶向在前列腺肿瘤上普遍存在的肿瘤抗原的抗体以及用于缓解表达该抗原的癌症的方法，以及用于表达该抗体的核酸和细胞。
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公开(公告)号：US09028824B2
公开(公告)日：2015-05-12
申请号：US13474466
申请日：2012-05-17
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20120202285A1
公开(公告)日：2012-08-09
申请号：US13454296
申请日：2012-04-24
申请人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
发明人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
摘要翻译： 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。
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公开(公告)号：US08236930B2
公开(公告)日：2012-08-07
申请号：US13099196
申请日：2011-05-02
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC分类号： C07K16/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20120045443A1
公开(公告)日：2012-02-23
申请号：US13198979
申请日：2011-08-05
IPC分类号： A61K39/395 , C12N15/13 , A61P25/28 , A61P25/00 , C12N5/10 , A61K31/7088 , C12N15/63 , C12N5/16 , C12N5/0793 , C12N1/21 , C07K16/28 , A61P25/02
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要： The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译： 本发明涉及模拟NT-3（trkC的天然配体）的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途，包括与急性神经细胞系统损伤和慢性神经变性疾病（包括周围神经病变）相关的神经细胞损伤。
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公开(公告)号：US20120009622A1
公开(公告)日：2012-01-12
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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