公开(公告)号：US20230183171A1

公开(公告)日：2023-06-15

申请号：US17925873

申请日：2021-05-20

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Joachim Gebhardt ,  Guillaume Michel Jacques Garivet ,  Harish Shinde ,  Roland Goetz

IPC: C07C259/18 ,  C12P13/00 ,  C07D271/06

CPC classification number: C07C259/18 ,  C12P13/002 ,  C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 4-(N′-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

公开(公告)号：US20210380569A1

公开(公告)日：2021-12-09

申请号：US17288976

申请日：2019-10-28

Applicant: BASF SE

Inventor： Roland Goetz ,  Michael Rack ,  Martin John McLaughlin ,  Harish Shinde ,  Ritesh Karalkar ,  Kailaskumar Borate ,  Karsten Koerber ,  Arun Narine ,  Nikolas Huwyler

IPC: C07D413/04 ,  B01J31/02

Abstract: The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 80% ee; by oxo-Michael addition of hydroxyl amine or its salt to an enone of formula (II), wherein the variables have the meanings given for formula (I), in the presence of a catalyst of formula (III) and a base.

公开(公告)号：US11034703B2

公开(公告)日：2021-06-15

申请号：US16610186

申请日：2018-05-02

Applicant: BASF SE

Inventor： Harish Shinde ,  Christopher Koradin ,  Joachim Dickhaut ,  Roland Goetz ,  Eric George Klauber ,  Sukunath Narayanan ,  Dhanyakumar Raut

IPC: C07D513/04 ,  C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07D419/04 ,  C07C403/04

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

公开(公告)号：US10149477B2

公开(公告)日：2018-12-11

申请号：US15517189

申请日：2015-10-06

Applicant: BASF SE

Inventor： Joachim Dickhaut ,  Arun Narine ,  Wolfgang von Deyn ,  Raffael Koller ,  Jean-Yves Wach ,  Devendra Vyas ,  Ashokkumar Adisechan ,  Harish Shinde

IPC: C07D513/04 ,  C07D495/04 ,  A01N43/90 ,  A01N43/02 ,  A01N43/48 ,  C07D487/04 ,  A01N25/02 ,  A61K31/513 ,  A61K31/519

Abstract: Substituted pyrimidinium compounds of the general formula (I): wherein the compounds are useful for controlling invertebrate pests.

公开(公告)号：US20170295791A1

公开(公告)日：2017-10-19

申请号：US15517189

申请日：2015-10-06

Applicant: BASF SE

Inventor： Joachim Dickhaut ,  Arun Narine ,  Wolfgang von Deyn ,  Raffael Koller ,  Jean-Yves Wach ,  Devendra Vyas ,  Ashokkumar Adisechan ,  Harish Shinde

IPC: A01N43/90 ,  C07D487/04 ,  A01N43/02 ,  A01N25/02 ,  A61K31/513 ,  A01N43/48 ,  C07D513/04 ,  A61K31/519

CPC classification number: A01N43/90 ,  A01N25/02 ,  A01N43/02 ,  A01N43/48 ,  A01N2300/00 ,  A61K31/513 ,  A61K31/519 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: Substituted pyrimidinium compounds of the general formula (I): wherein the compounds are useful for controlling invertebrate pests.

公开(公告)号：US20240262816A1

公开(公告)日：2024-08-08

申请号：US18282874

申请日：2022-03-25

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Christopher Koradin ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Goetz

IPC: C07D417/12 ,  B01J31/18

CPC classification number: C07D417/12 ,  B01J31/189

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one of the formula (I) by hydrogenation of 2-[2-(2-chlorothia-201-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one (1) in the presence of a chiral transition metal catalyst.

公开(公告)号：US20240116916A1

公开(公告)日：2024-04-11

申请号：US18272913

申请日：2022-01-21

Applicant: BASF SE

Inventor： Martin John McLaughlin ,  Christopher Koradin ,  Rahul Kaduskar ,  Harish Shinde ,  Roland Gotez ,  Guillaume Michel Jacques Garivet

IPC: C07D417/12 ,  B01J31/18

CPC classification number: C07D417/12 ,  B01J31/1805 ,  C07B2200/07

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

公开(公告)号：US20240051929A1

公开(公告)日：2024-02-15

申请号：US17641989

申请日：2020-09-28

Applicant: BASF SE

Inventor： Harish Shinde ,  Rahul Kaduskar ,  Christopher Koradin ,  Martin John McLaughlin ,  Roland Goetz ,  Sunil Khamkar

IPC: C07D277/32

CPC classification number: C07D277/32

Abstract: The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

公开(公告)号：US20230416273A1

公开(公告)日：2023-12-28

申请号：US18272884

申请日：2022-01-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Martin John McLaughlin ,  Harish Shinde ,  Rahul Kaduskar ,  Ronald Goetz ,  Guillaaume Michel Jaques Garivet

IPC: C07D513/04

CPC classification number: C07D513/04

Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.

公开(公告)号：US20230066401A1

公开(公告)日：2023-03-02

申请号：US17795941

申请日：2021-02-01

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Christopher Koradin ,  Roland Goetz ,  Harish Shinde

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.