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公开(公告)号：US20240317881A1
公开(公告)日：2024-09-26
申请号：US18420021
申请日：2024-01-23
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Grietje ANDRINGA , Frank BEURSKENS , Janine SCHUURMAN , David P.E. SATIJN , Tahamtan AHMADI
CPC classification number: C07K16/2896 , A61P35/00 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
Abstract: Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index.
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公开(公告)号：US20220169738A1
公开(公告)日：2022-06-02
申请号：US17369542
申请日：2021-07-07
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20210107985A1
公开(公告)日：2021-04-15
申请号：US16883333
申请日：2020-05-26
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , G01N33/68 , A61K39/395 , A61K45/06 , A61N5/06 , C07K16/42 , C07K16/46 , G01N33/574 , G01N33/569
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20180201693A1
公开(公告)日：2018-07-19
申请号：US15742803
申请日：2016-07-01
Applicant: GENMAB A/S
Inventor： Richard G. HIBBERT , Aran F. LABRIJN , Arnout F. GERRITSEN , Janine SCHUURMAN , Paul PARREN
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
Abstract: Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies based on a differential affinity towards an affinity reagent.
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公开(公告)号：US20170369594A1
公开(公告)日：2017-12-28
申请号：US15599395
申请日：2017-05-18
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Joyce I. MEESTERS , Bart DE GOEIJ , Aran Frank LABRIJN , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170327597A1
公开(公告)日：2017-11-16
申请号：US15536143
申请日：2015-12-18
Applicant: GENMAB A/S
Inventor： Aran F. LABRIJN , Joyce I. MEESTERS , Janine SCHUURMAN , Paul PARREN , Anthony ARMSTRONG , Matthew BUNCE , Mark CHIU , Thomas NESSPOR , Adam ZWOLAK
CPC classification number: C07K16/462 , A61K49/0008 , C07K16/00 , C07K16/2809 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/64 , C07K2317/73
Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.
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公开(公告)号：US20170240640A1
公开(公告)日：2017-08-24
申请号：US15420824
申请日：2017-01-31
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G. J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , G01N33/569 , C07K16/42 , G01N33/68 , A61K45/06 , A61K39/395
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：US20150259424A1
公开(公告)日：2015-09-17
申请号：US14592558
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Catharina Emanuele Gerarda HAVENITH , Paul PARREN , Jan G.J. VAN DE WINKEL , Denise Leah WILLIAMS , Jørgen PETERSEN , Ole BAADSGAARD
IPC: C07K16/28 , A61K45/06 , A61N5/06 , C07K16/46 , G01N33/574 , A61K39/395 , C07K16/42
CPC classification number: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20240209117A1
公开(公告)日：2024-06-27
申请号：US18507869
申请日：2023-11-13
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Edwald T. J. VAN DER BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , G01N33/6854 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
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公开(公告)号：US20210061919A1
公开(公告)日：2021-03-04
申请号：US16947021
申请日：2020-07-15
Applicant: GENMAB A/S
Inventor： Jan VAN DE WINKEL , Tom VINK , Janine SCHUURMAN , Paul PARREN , Rob AALBERSE , Marijn VAN DER NEUT KOLFSCHOTEN
Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
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