公开(公告)号：US12226551B2

公开(公告)日：2025-02-18

申请号：US16526912

申请日：2019-07-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Ming Dang ,  Yen-Lane Chen

IPC: A61L31/10 ,  A61K31/436 ,  A61K47/34 ,  A61K47/38 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16

Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.

公开(公告)号：US20250032416A1

公开(公告)日：2025-01-30

申请号：US18917556

申请日：2024-10-16

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K31/337 ,  A61K49/00

Abstract: Polymer microspheres containing poly-lactide-co-glycolide (PLGA) and therapeutic agent are described. Also described are methods of making such polymer microspheres and methods of using such polymer microspheres for embolizing blood vessels.

公开(公告)号：US11814397B2

公开(公告)日：2023-11-14

申请号：US17200434

申请日：2021-03-12

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Yen-Lane Chen

IPC: C07D493/16

CPC classification number: C07D493/16 ,  C07B2200/13

Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.

公开(公告)号：US20220160997A1

公开(公告)日：2022-05-26

申请号：US17532921

申请日：2021-11-22

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Dongming Hou ,  Hongxia Zeng ,  Tim O'Connor ,  Bryan Allen Clark

IPC: A61M25/01 ,  A61M25/00 ,  A61M25/06

Abstract: A radiopaque anchor and delivery device system may comprise a pigtail catheter and a radiopaque anchor. The pigtail catheter may be a dual lumen catheter configured to deploy the radiopaque anchor and delivery a radiopaque fluid or contrast agent. The implantable radiopaque anchor may be slidably disposed within and deployable from a lumen of the elongate shaft.

公开(公告)号：US20200093745A1

公开(公告)日：2020-03-26

申请号：US16597122

申请日：2019-10-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K31/337 ,  A61K49/00

Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided.

公开(公告)号：US20150182732A1

公开(公告)日：2015-07-02

申请号：US14583941

申请日：2014-12-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Yen-Lane Chen ,  Steven L. Kangas

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/63 ,  A61M2025/1031

Abstract: A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5° of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.

Abstract translation: 导管包括具有药物包衣的医用气囊。 药物涂层包括在气球表面上的药物晶体。 球囊表面上的大部分药物晶体是定向药物晶体，其相对于晶体延伸的球囊表面在预定的非零公共角度的5°内延伸。