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    Medical Device with Crystalline Drug Coating
    1.
    发明申请
    Medical Device with Crystalline Drug Coating 审中-公开
    具有结晶药物涂层的医疗器械

    公开(公告)号：US20150250772A1

    公开(公告)日：2015-09-10

    申请号：US14719599

    申请日：2015-05-22

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Steven L. Kangas ,  James Q. Feng ,  Hongxia Zeng ,  Yen-Lane Chen

    IPC: A61K31/436 ,  A61L27/54 ,  A61L29/08 ,  A61L27/28

    CPC classification number: A61K31/436 ,  A61F2/00 ,  A61F2/02 ,  A61K31/337 ,  A61L27/28 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/416 ,  A61L2300/63 ,  C09D5/16

    Abstract: A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

    Abstract translation: 一种具有无聚合物外表面层的医疗装置，其包含选自依维莫司，他克莫司，西罗莫司，佐他莫司，生物利莫霉素和雷帕霉素的结晶药物。 该装置可以通过包括以下步骤的方法制造：提供医疗装置; 将所述药物的溶液施加到所述外表面的所述部分以形成无定形药物的包衣; 并用溶剂蒸气对药物进行蒸汽退火以形成结晶药物; 其中在施加药物溶液之前或之后，在装置的外表面的至少所述部分上施加具有最大粒径为约10μm以下的所述药物的结晶形式的晶种层，但是在汽化退火之前 涂层。

    Lubricious Coating Compositions
    2.
    发明申请
    Lubricious Coating Compositions 审中-公开
    润滑涂料组合物

    公开(公告)号：US20150018431A1

    公开(公告)日：2015-01-15

    申请号：US14330734

    申请日：2014-07-14

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Hongxia Zeng ,  Jan Seppala ,  Yen-Lane Chen ,  Raghav Goel

    IPC: C10M107/42

    CPC classification number: C10M107/42 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  C08L39/06

    Abstract: In one aspect, the present disclosure pertains to lubricous coating compositions that comprise (a) a higher molecular weight polyvinylpyrrolidone, (b) a lower molecular weight polyvinylpyrrolidone, and (c) a polyfunctional unsaturated crosslinking agent. In some embodiments, such lubricous coating compositions are present in crosslinked form on the surface of a medical article. In some embodiments, the lubricous coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently crosslinked, thereby forming a lubricious coating on the substrate. In another aspect, the present disclosure is directed to methods for forming various medical articles.

    Abstract translation: 一方面，本公开内容涉及包含（a）较高分子量聚乙烯吡咯烷酮，（b）较低分子量聚乙烯吡咯烷酮和（c）多官能不饱和交联剂的润滑涂料组合物。 在一些实施方案中，这种润滑涂料组合物以交联形式存在于医疗制品的表面上。 在一些实施方案中，润滑涂料组合物还包含溶剂，在这种情况下，这种组合物可以例如以层的形式施用于基底并随后交联，从而在基底上形成润滑涂层。 在另一方面，本公开涉及用于形成各种医疗制品的方法。

    DIRECT ORAL ANTICOAGULANT-ELUTING MEDICAL DEVICE
    5.
    发明申请
    DIRECT ORAL ANTICOAGULANT-ELUTING MEDICAL DEVICE 有权

    公开(公告)号：US20230011767A1

    公开(公告)日：2023-01-12

    申请号：US17860848

    申请日：2022-07-08

    Applicant: BOSTON SCIENTIFIC SCIMED, INC.

    Inventor： Steven L. Kangas ,  Edward Kopesky ,  Yen-Lane Chen

    IPC: A61B17/12 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/444

    Abstract: A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.

    SYSTEMS AND METHODS FOR TREATING ATHEROSCLEROTIC PLAQUE
    7.
    发明申请
    SYSTEMS AND METHODS FOR TREATING ATHEROSCLEROTIC PLAQUE 审中-公开
    用于治疗甲状腺功能障碍的系统和方法

    公开(公告)号：US20150351782A1

    公开(公告)日：2015-12-10

    申请号：US14734446

    申请日：2015-06-09

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Steven L. Kangas ,  Yen-Lane Chen

    IPC: A61B17/22 ,  A61B17/3207

    CPC classification number: A61B17/22 ,  A61B17/3207 ,  A61B2017/22061 ,  A61B2017/22065 ,  A61B2017/22067 ,  A61B2017/22071 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2017/22095 ,  A61B2017/320733

    Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.

    Abstract translation: 一种治疗动脉粥样硬化斑块的系统和方法。 该系统包括包括可膨胀气囊的第一导管和包括与远端孔流体连通的内腔的第二导管。 该方法包括将第一导管插入与斑块形成相邻的体腔内，并且从邻近斑块形成的第一导管展开球囊。 另外，该方法包括将第二导管插入到与第一导管相邻的位置，并沿着第一导管的展开球囊的至少一部分布置第二导管的远端部分。 此外，该方法包括将第二导管的至少一部分路由到与动脉粥样硬化斑块相邻的亚底层空间内。 此外，该方法包括将治疗剂注射到与动脉粥样硬化斑块相邻的内膜下空间。

    SYSTEMS AND METHODS FOR DELIVERING DRUGS TO A TREATMENT SITE
    8.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERING DRUGS TO A TREATMENT SITE 审中-公开
    将药物递送至治疗场所的系统和方法

    公开(公告)号：US20150238736A1

    公开(公告)日：2015-08-27

    申请号：US14634085

    申请日：2015-02-27

    Applicant: BOSTON SCIENTIFIC SCIMED, INC.

    Inventor： Hongxia Zeng ,  Yen-Lane Chen ,  Steven L. Kangas

    IPC: A61M25/10

    CPC classification number: A61M25/1011 ,  A61M25/1002 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1059 ,  A61M2025/1061 ,  A61M2025/1072

    Abstract: A catheter system includes a catheter having a first balloon and a second balloon. The first balloon is longitudinally offset from the second balloon along the length of the catheter. The first and second balloons both have expanded and unexpanded states. The second balloon has a drug coating. The catheter system has a first configuration, a second configuration, and a third configuration. In the first configuration, the first balloon is in the unexpanded state and the second balloon is in the unexpanded state. In the second configuration, the first balloon is in the expanded state and the second balloon is in the unexpanded state. In the third configuration, the first balloon is in the expanded state and the second balloon is in the expanded state.

    Abstract translation: 导管系统包括具有第一气囊和第二气囊的导管。 第一气球沿着导管的长度纵向偏离第二球囊。 第一和第二个气球都有扩张和未膨胀的状态。 第二个气球有药物涂层。 导管系统具有第一构造，第二构造和第三构造。 在第一构造中，第一气球处于未膨胀状态，第二气球处于未膨胀状态。 在第二构造中，第一气囊处于膨胀状态，第二气囊处于未膨胀状态。 在第三构造中，第一气囊处于膨胀状态，第二气囊处于膨胀状态。

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