公开(公告)号：US20240307594A1

公开(公告)日：2024-09-19

申请号：US18606526

申请日：2024-03-15

Applicant: Boston Scientific Scimed, Inc.

Inventor： Jonathan Pascal Chaky ,  Ryan Lee Reifsteck ,  Aaron Cooper Foss ,  Nicholas Michael Job

IPC: A61L31/16 ,  A61L31/04

CPC classification number: A61L31/16 ,  A61L31/042 ,  A61L2300/216 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

Abstract: A medical device may be coated with a therapeutic composition that includes everolimus. Everolimus crystals may be coated with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition. The medical device may be contacted with the coating composition in order to form a coating on the medical device. Coating the everolimus crystals with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition may include suspending everolimus crystals in a first solution that includes acetyl tri-butyl citrate (ATBC) and adding a second solution to the first solution, the second solution including ethyl cellulose (EC), the EC mixing with the ATBC and coating the everolimus crystals, thereby forming a coating suspension including coated everolimus crystals in the suspension.

公开(公告)号：US12226551B2

公开(公告)日：2025-02-18

申请号：US16526912

申请日：2019-07-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Ming Dang ,  Yen-Lane Chen

IPC: A61L31/10 ,  A61K31/436 ,  A61K47/34 ,  A61K47/38 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16

Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.

公开(公告)号：US11814397B2

公开(公告)日：2023-11-14

申请号：US17200434

申请日：2021-03-12

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Yen-Lane Chen

IPC: C07D493/16

CPC classification number: C07D493/16 ,  C07B2200/13

Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.