公开(公告)号：US12226551B2

公开(公告)日：2025-02-18

申请号：US16526912

申请日：2019-07-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Ming Dang ,  Yen-Lane Chen

IPC: A61L31/10 ,  A61K31/436 ,  A61K47/34 ,  A61K47/38 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16

Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.

公开(公告)号：US20250032416A1

公开(公告)日：2025-01-30

申请号：US18917556

申请日：2024-10-16

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K31/337 ,  A61K49/00

Abstract: Polymer microspheres containing poly-lactide-co-glycolide (PLGA) and therapeutic agent are described. Also described are methods of making such polymer microspheres and methods of using such polymer microspheres for embolizing blood vessels.

公开(公告)号：US11814397B2

公开(公告)日：2023-11-14

申请号：US17200434

申请日：2021-03-12

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Hongxia Zeng ,  Jonathan Pascal Chaky ,  Yen-Lane Chen

IPC: C07D493/16

CPC classification number: C07D493/16 ,  C07B2200/13

Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.

公开(公告)号：US20200093745A1

公开(公告)日：2020-03-26

申请号：US16597122

申请日：2019-10-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K31/337 ,  A61K49/00

Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided.

公开(公告)号：US10098650B2

公开(公告)日：2018-10-16

申请号：US14734446

申请日：2015-06-09

Applicant: Boston Scientific Scimed, Inc.

Inventor： Steven L. Kangas ,  Yen-Lane Chen

IPC: A61B17/22 ,  A61B17/3207

Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.

公开(公告)号：US20150182732A1

公开(公告)日：2015-07-02

申请号：US14583941

申请日：2014-12-29

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Yen-Lane Chen ,  Steven L. Kangas

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/63 ,  A61M2025/1031

Abstract: A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5° of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.

Abstract translation: 导管包括具有药物包衣的医用气囊。 药物涂层包括在气球表面上的药物晶体。 球囊表面上的大部分药物晶体是定向药物晶体，其相对于晶体延伸的球囊表面在预定的非零公共角度的5°内延伸。