公开(公告)号：US20230130516A1

公开(公告)日：2023-04-27

申请号：US17792878

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qian ZHANG ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Qiang CONG ,  Yam B. POUDEL ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5377 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20200048254A1

公开(公告)日：2020-02-13

申请号：US16659735

申请日：2019-10-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K31/52 ,  A61K47/68 ,  A61K47/60 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20190055247A1

公开(公告)日：2019-02-21

申请号：US16103619

申请日：2018-08-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20190055243A1

公开(公告)日：2019-02-21

申请号：US16103210

申请日：2018-08-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR ,  Prasanna SIVAPRAKASAM ,  Shoshana L. POSY

IPC: C07D473/18

Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20230122249A1

公开(公告)日：2023-04-20

申请号：US17793162

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Daniel O'MALLEY ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH,Murugaiah

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20200317672A1

公开(公告)日：2020-10-08

申请号：US16904337

申请日：2020-06-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04 ,  A61K47/60 ,  A61K47/68 ,  A61K31/52

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200255429A1

公开(公告)日：2020-08-13

申请号：US16865009

申请日：2020-05-01

Applicant: Bristol-Myers Squibb Company

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200048255A1

公开(公告)日：2020-02-13

申请号：US16660365

申请日：2019-10-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K47/68 ,  A61K47/60 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200024279A1

公开(公告)日：2020-01-23

申请号：US16583869

申请日：2019-09-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR ,  Prasanna SIVAPRAKASAM ,  Shoshana L. POSY

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.