公开(公告)号：US20220324829A1

公开(公告)日：2022-10-13

申请号：US17224161

申请日：2021-04-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YAN SHI ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  C07C249/06 ,  C07C403/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11008300B2

公开(公告)日：2021-05-18

申请号：US16744303

申请日：2020-01-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  A61P1/16 ,  A61P19/10 ,  A61P13/12 ,  A61P11/00 ,  C07C249/06 ,  C07C403/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11007180B2

公开(公告)日：2021-05-18

申请号：US16732387

申请日：2020-01-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: C07D401/04 ,  A61K31/4192 ,  C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/454 ,  A61K31/41 ,  C07C62/10

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US10071078B2

公开(公告)日：2018-09-11

申请号：US15628104

申请日：2017-06-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: C07D401/04 ,  A61K31/4192 ,  A61K31/27 ,  A61K31/454 ,  C07D401/14 ,  C07D249/06 ,  A61K31/41 ,  C07C62/10

CPC classification number: A61K31/4192 ,  A61K31/27 ,  A61K31/41 ,  A61K31/454 ,  C07C62/10 ,  C07D249/06 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20160039780A1

公开(公告)日：2016-02-11

申请号：US14774276

申请日：2014-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Hao Zhang ,  Peter T.W. Cheng ,  Shiwei Tao

IPC: C07D307/79 ,  A61K45/06 ,  C07C255/54 ,  A61K31/192 ,  C07D231/12 ,  A61K31/415 ,  C07C59/72 ,  A61K31/343 ,  A61K31/277

CPC classification number: C07D307/79 ,  A61K31/192 ,  A61K31/277 ,  A61K31/343 ,  A61K31/415 ,  A61K45/06 ,  C07C59/72 ,  C07C255/54 ,  C07C2602/44 ,  C07D231/12

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR120G蛋白偶联受体调节剂。

公开(公告)号：US20230339884A1

公开(公告)日：2023-10-26

申请号：US18321092

申请日：2023-05-22

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  C07C249/06 ,  C07D401/04 ,  C07C403/04

CPC classification number: C07D401/04 ,  A61P35/00 ,  C07C249/06 ,  C07C403/04 ,  C07D249/06 ,  C07D403/04 ,  A61P1/16

Abstract: The present invention provides compounds of Formula (I):





or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11319315B2

公开(公告)日：2022-05-03

申请号：US16772842

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Li ,  Tianan Fang ,  James R. Corte ,  Jun Shi ,  Hao Zhang ,  Lawrence J. Kennedy ,  Shiwei Tao

IPC: C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20210230143A1

公开(公告)日：2021-07-29

申请号：US16772825

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Ying Wang ,  Peter Tai Wah Cheng ,  Jun Shi ,  Shiwei Tao ,  James R. Corte ,  Tianan Fang ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Sutjano Jusuf

IPC: C07D401/14 ,  C07D409/14 ,  C07D403/14 ,  C07D401/12 ,  C07D405/14 ,  C07D491/052

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US10662172B2

公开(公告)日：2020-05-26

申请号：US16223169

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  A61P1/16 ,  A61P19/10 ,  A61P13/12 ,  A61P11/00 ,  C07C403/04 ,  C07C249/06

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20200148665A1

公开(公告)日：2020-05-14

申请号：US16744303

申请日：2020-01-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  A61P35/00 ,  C07D249/06 ,  C07D403/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.