公开(公告)号：US20230390249A1

公开(公告)日：2023-12-07

申请号：US18453431

申请日：2023-08-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/454 ,  C07D401/04

CPC classification number: A61K31/4192 ,  C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/454 ,  C07D401/04 ,  A61K31/41

Abstract: The present invention provides compounds of Formula (I):






or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11697646B2

公开(公告)日：2023-07-11

申请号：US17224161

申请日：2021-04-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  A61P1/16 ,  A61P19/10 ,  A61P13/12 ,  A61P11/00 ,  C07C249/06 ,  C07C403/04

CPC classification number: C07D401/04 ,  A61P35/00 ,  C07C249/06 ,  C07C403/04 ,  C07D249/06 ,  C07D403/04 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12 ,  A61P19/10

Abstract: The present invention provides compounds of Formula (I):




or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20200317662A1

公开(公告)日：2020-10-08

申请号：US16954556

申请日：2018-12-18

Applicant: Bristol-Myers Squibb Company

Inventor： Peter Tai Wah Cheng ,  Yan Shi ,  Hao Zhang

IPC: C07D417/14 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (Ia) or (Ib):Formula (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20190185446A1

公开(公告)日：2019-06-20

申请号：US16223169

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YAN SHI ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D401/04 ,  C07D403/04 ,  C07D249/06

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20170360759A1

公开(公告)日：2017-12-21

申请号：US15628104

申请日：2017-06-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun LI ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  A61K31/27 ,  C07D401/04 ,  A61K31/454 ,  C07C62/10 ,  A61K31/41

CPC classification number: A61K31/4192 ,  A61K31/27 ,  A61K31/41 ,  A61K31/454 ,  C07C62/10 ,  C07D249/06 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20160016880A1

公开(公告)日：2016-01-21

申请号：US14774289

申请日：2014-03-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter T.W. Cheng ,  Ying Wang ,  Shung C. Wu ,  Hao Zhang

IPC: C07C59/13 ,  A61K31/415 ,  A61K31/192 ,  C07D307/79 ,  A61K31/343 ,  C07D333/56 ,  A61K31/381 ,  C07D271/06 ,  A61K31/4245 ,  C07C59/215 ,  C07C323/19 ,  C07C205/34 ,  C07D333/28 ,  C07D239/38 ,  A61K31/505 ,  C07D205/04 ,  A61K31/397 ,  A61K45/06 ,  C07D231/12

CPC classification number: C07C59/13 ,  A61K31/192 ,  A61K31/343 ,  A61K31/381 ,  A61K31/397 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/505 ,  A61K45/06 ,  C07C43/192 ,  C07C43/196 ,  C07C47/277 ,  C07C59/215 ,  C07C59/72 ,  C07C62/34 ,  C07C69/675 ,  C07C69/708 ,  C07C69/732 ,  C07C69/734 ,  C07C69/736 ,  C07C69/757 ,  C07C69/76 ,  C07C205/34 ,  C07C235/26 ,  C07C237/22 ,  C07C311/51 ,  C07C323/19 ,  C07C2601/02 ,  C07C2602/08 ,  C07C2602/42 ,  C07D205/04 ,  C07D231/12 ,  C07D239/38 ,  C07D271/06 ,  C07D307/79 ,  C07D333/16 ,  C07D333/28 ,  C07D333/56

Abstract: The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Abstract translation: 本发明提供式（I）的化合物：（I）或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR120G蛋白偶联受体调节剂。

公开(公告)号：US08962660B2

公开(公告)日：2015-02-24

申请号：US14205421

申请日：2014-03-12

Applicant: Bristol-Myers Squibb Company

Inventor： Hao Zhang ,  Peter T. W. Cheng ,  Sean Chen ,  Shiwei Tao ,  Shung C. Wu ,  Lidet A Negash

IPC: A61K45/06 ,  A61K31/4433 ,  A61K31/427 ,  A61K31/4245 ,  A61K31/4196 ,  C07D493/08 ,  A61K31/35

CPC classification number: C07D493/08 ,  A61K31/35 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物或其立体异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR120G蛋白偶联受体调节剂。

公开(公告)号：US20250057815A1

公开(公告)日：2025-02-20

申请号：US18822597

申请日：2024-09-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  A61K31/27 ,  A61K31/41 ,  A61K31/454 ,  C07C62/10 ,  C07D249/06 ,  C07D401/04 ,  C07D401/14

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11352345B2

公开(公告)日：2022-06-07

申请号：US16954320

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Hao Zhang ,  Jun Li ,  Tianan Fang ,  James R. Corte

IPC: C07D403/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11261174B2

公开(公告)日：2022-03-01

申请号：US16954221

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Jun Li ,  Yan Shi ,  Ying Wang ,  Hao Zhang ,  Lawrence J. Kennedy ,  Steven J. Walker ,  Ramesh Babu Reddigunta

IPC: C07D231/12 ,  C07D401/04 ,  C07D403/04 ,  A61K31/415 ,  A61K31/4427 ,  A61K31/496 ,  A61P43/00 ,  A61P17/02 ,  A61P35/00

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.