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公开(公告)号：US20230125059A1
公开(公告)日：2023-04-20
申请号：US18052544
申请日：2022-11-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Stephen L. SWIHART , Eli A. HEFNER , Michael GRIFFIN , Li LU
Abstract: A fluorescence detection system, including apparatus and methods, suitable for qPCR and other fluorescence-based analyses. The system may comprise various components, including a stage, an illumination module, a detection module, and an optical relay structure. The stage may be configured to support a sample holder. The illumination module may include one or more discrete light sources configured to produce excitation light. The detection module may be configured to detect fluorescence emission light produced, in response to the excitation light, by a fluorescent sample positioned in the sample holder. The optical relay structure may include a beamsplitter assembly configured to direct the excitation light from the illumination module along an illumination path to the sample holder and to direct the fluorescence emission light from the sample holder along a response path to the imaging module. The system may enhance the quality of excitation light hitting samples in the sample holder.
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12.发明申请公开(公告)号：US20220026390A1
公开(公告)日：2022-01-27
申请号：US17386246
申请日：2021-07-27
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Stephen L. SWIHART , Kevin Alan MCDONALD
IPC: G01N27/447 , G01N33/68 , G01N21/64
Abstract: An electrophoresis apparatus with minimal autofluorescence to enable gel processing in situ, and methods of making and using the electrophoresis apparatus. An exemplary electrophoresis apparatus may comprise a cassette defining a cavity between a first pane and a second pane of a double-paned viewing window, and also may comprise a slab gel located in the cavity. The viewing window may be transparent to ultraviolet light that drives a derivatization reaction in the slab gel, and, absent the slab gel, may define a window autofluorescence inducible by irradiation with the ultraviolet light. The window autofluorescence, per unit area, may be less than five-fold a gel autofluorescence of the slab gel, per the same unit area and under the same irradiation with the ultraviolet light.
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公开(公告)号：US20170276605A1
公开(公告)日：2017-09-28
申请号：US15471264
申请日：2017-03-28
Applicant: Bio-Rad Laboratories, Inc.
Inventor： John BARICH , Renee LEMAIRE-ADKINS , David NEAZ , Ariel NOTCOVICH , Paul PATT , Ryan SHORT , Steven SWIHART , Evan THRUSH , Trey MARLOWE
Abstract: Analyte arrays such as solutes in a slab-shaped gel following electrophoresis, and particularly arrays that are in excess of 3 cm square and up to 25 cm square and higher, are imaged at distances of 5 cm or less by either forming sub-images of the entire array and stitching together the sub-images by computer-based stitching technology, or by using an array of thin-film photoresponsive elements that is coextensive with the analyte array to form a single image of the array.
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公开(公告)号：US20170016829A1
公开(公告)日：2017-01-19
申请号：US15211728
申请日：2016-07-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve SWIHART , Evan THRUSH , Yochanan URI , Boaz RAN , Itay BARAK , Kevin MCDONAL
CPC classification number: G02B6/08 , G01N21/6454 , G01N27/44721 , G01N2021/6484 , G02B5/22 , G02B5/28
Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.
Abstract translation: 提供了用于接触成像的设备，系统，方法和套件。 接触成像装置包括成像传感器，机械耦合到成像传感器的固定光纤面板以及机械耦合到固定光纤面板的光学滤光层。 光学滤光层可以包括干涉滤光器，吸收滤光器和/或可移除的光纤面板。 接触成像装置可用于通过基于波长和/或入射角滤除激发光来对荧光样品进行成像。
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