公开(公告)号：US20170332001A1

公开(公告)日：2017-11-16

申请号：US15667435

申请日：2017-08-02

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steve SWIHART ,  Evan THRUSH ,  Boaz RAN

IPC: H04N5/235 ,  H04N5/361 ,  G01N21/76 ,  H04N5/365 ,  H04N5/355 ,  G01N21/27 ,  G01N21/64

CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

公开(公告)号：US20170366768A1

公开(公告)日：2017-12-21

申请号：US15675494

申请日：2017-08-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Boaz RAN ,  Steve SWIHART ,  Evan THRUSH ,  Itay BARAK

IPC: H04N5/361 ,  H04N5/365

CPC classification number: H04N5/361 ,  H04N5/365

Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.

公开(公告)号：US20190072490A1

公开(公告)日：2019-03-07

申请号：US16110333

申请日：2018-08-23

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Steve SWIHART

IPC: G01N21/64 ,  G02B5/02

Abstract: Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.

公开(公告)号：US20170016829A1

公开(公告)日：2017-01-19

申请号：US15211728

申请日：2016-07-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Steve SWIHART ,  Evan THRUSH ,  Yochanan URI ,  Boaz RAN ,  Itay BARAK ,  Kevin MCDONAL

IPC: G01N21/64 ,  G02B5/22 ,  G02B5/28 ,  H04N5/225 ,  G02B6/08

CPC classification number: G02B6/08 ,  G01N21/6454 ,  G01N27/44721 ,  G01N2021/6484 ,  G02B5/22 ,  G02B5/28

Abstract: Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.

Abstract translation: 提供了用于接触成像的设备，系统，方法和套件。 接触成像装置包括成像传感器，机械耦合到成像传感器的固定光纤面板以及机械耦合到固定光纤面板的光学滤光层。 光学滤光层可以包括干涉滤光器，吸收滤光器和/或可移除的光纤面板。 接触成像装置可用于通过基于波长和/或入射角滤除激发光来对荧光样品进行成像。