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    SYSTEM AND METHOD FOR RAPID MULTIPLEXED SAMPLE PROCESSING WITH APPLICATIONS FOR NUCLEIC ACID AMPLIFICATION ASSAYS
    13.
    发明申请
    SYSTEM AND METHOD FOR RAPID MULTIPLEXED SAMPLE PROCESSING WITH APPLICATIONS FOR NUCLEIC ACID AMPLIFICATION ASSAYS 有权

    公开(公告)号：US20250041846A1

    公开(公告)日：2025-02-06

    申请号：US18808643

    申请日：2024-08-19

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan HANDIQUE ,  Ronald LEBOFSKY

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.

    MULTIPLE BEADS PER DROPLET RESOLUTION
    14.
    发明公开
    MULTIPLE BEADS PER DROPLET RESOLUTION 审中-公开

    公开(公告)号：US20230390726A1

    公开(公告)日：2023-12-07

    申请号：US18233235

    申请日：2023-08-11

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Ronald LEBOFSKY ,  Nicholas HEREDIA

    IPC: B01J19/00 ,  C12Q1/6806

    CPC classification number: B01J19/0046 ,  C12Q1/6806 ,  B01J2219/00547 ,  B01J2219/00596 ,  B01J2219/00722

    Abstract: Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided. In one aspect, the method comprises: partitioning a sample into a plurality of partitions comprising a particle comprising a solid support surface, the solid support surface having a plurality of oligonucleotide primers conjugated thereon, wherein the oligonucleotide primers comprise a barcode sequence, and wherein the partitions have 0, 1, or more than 1 particles per partition; providing in a partition a substrate comprising a barcode sequence or repeating clonal barcode sequences; and in the partition, associating a first particle conjugated to oligonucleotide primers comprising a first barcode sequence and a second particle conjugated to oligonucleotide primers comprising a second barcode sequence to a barcode sequence from the substrate, thereby generating a nucleic acid signature for the particles in the partition.

    MULTIPLE BEADS PER DROPLET RESOLUTION
    17.
    发明申请
    MULTIPLE BEADS PER DROPLET RESOLUTION 审中-公开

    公开(公告)号：US20200324264A1

    公开(公告)日：2020-10-15

    申请号：US16911961

    申请日：2020-06-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Ronald LEBOFSKY ,  Nicholas HEREDIA

    IPC: B01J19/00 ,  C12Q1/6806

    Abstract: Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided. In one aspect, the method comprises: partitioning a sample into a plurality of partitions comprising a particle comprising a solid support surface, the solid support surface having a plurality of oligonucleotide primers conjugated thereon, wherein the oligonucleotide primers comprise a barcode sequence, and wherein the partitions have 0, 1, or more than 1 particles per partition; providing in a partition a substrate comprising a barcode sequence or repeating clonal barcode sequences; and in the partition, associating a first particle conjugated to oligonucleotide primers comprising a first barcode sequence and a second particle conjugated to oligonucleotide primers comprising a second barcode sequence to a barcode sequence from the substrate, thereby generating a nucleic acid signature for the particles in the partition.

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