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公开(公告)号：US20170080068A1
公开(公告)日：2017-03-23
申请号：US15220973
申请日：2016-07-27
Applicant: BioNTech AG , Johannes Gutenberg-Universitat Mainz
Inventor： Ugur Sahin , Özlem Türeci , Michael Koslowski , Dirk Usener
CPC classification number: A61K39/0011 , A61K45/06 , A61K2039/5256 , A61K2039/54 , A61K2039/57 , A61K2039/572 , C07K14/4748 , C07K16/2803 , C07K16/30 , C07K2317/34 , C12Q1/6886 , C12Q2600/158 , G01N33/574
Abstract: The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
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公开(公告)号：US10526387B2
公开(公告)日：2020-01-07
申请号：US15341528
申请日：2016-11-02
Applicant: BioNTech AG
Inventor： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
IPC: C07K14/47 , A61K39/00 , C07K14/005 , C12N7/00
Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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公开(公告)号：US10253373B2
公开(公告)日：2019-04-09
申请号：US15591896
申请日：2017-05-10
Applicant: BioNTech AG , Johannes Gutenberg-Universität Mainz
Inventor： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC: C12Q1/68 , C12Q1/6886 , C07K14/47 , C07K16/30
Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
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14.发明申请公开(公告)号：US20160215351A1
公开(公告)日：2016-07-28
申请号：US15003530
申请日：2016-01-21
Applicant: BioNTech AG
Inventor： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C07K14/4748 , C07K16/30 , C12Q2600/118 , C12Q2600/158
Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
Abstract translation: 本技术涉及与癌症疾病相关的遗传产物。 本技术还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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Patent Agency Ranking
公开(公告)号：US20160002738A1
公开(公告)日：2016-01-07
申请号：US14796509
申请日：2015-07-10
Applicant: BioNTech AG
Inventor： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC: C12Q1/68
CPC classification number: C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
Abstract: The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
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公开(公告)号：US20170314078A1
公开(公告)日：2017-11-02
申请号：US15591896
申请日：2017-05-10
Applicant: BioNTech AG , Johannes Gutenberg-Universität Mainz
Inventor： Ugur Sahin , Özlem Türeci , Michael Koslowski
CPC classification number: C12Q1/6886 , C07K14/4748 , C07K16/30 , C12Q2600/118 , C12Q2600/158
Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
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公开(公告)号：US09617321B2
公开(公告)日：2017-04-11
申请号：US14457897
申请日：2014-08-12
Applicant: BioNTech AG
Inventor： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
IPC: A61K39/00 , C07K14/47 , C07K14/005 , C12N7/00
CPC classification number: C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
Abstract: The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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18.发明申请Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy 审中-公开鉴定表面相关抗原的肿瘤诊断和治疗公开(公告)号：US20170052187A1
公开(公告)日：2017-02-23
申请号：US14887979
申请日：2016-03-07
Applicant: BioNTech AG
Inventor： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schluter
IPC: G01N33/574 , G06F19/22 , C12Q1/68
CPC classification number: G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
Abstract translation: 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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19.发明申请IDENTIFICATION OF SURFACE-ASSOCIATED ANTIGENS FOR TUMOR DIAGNOSIS AND THERAPY 有权用于肿瘤诊断和治疗的表面相关抗原的鉴定公开(公告)号：US20140017679A1
公开(公告)日：2014-01-16
申请号：US13864411
申请日：2013-04-17
Applicant: BioNTech AG
Inventor： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Gerd Helftenbein , Dirk Usener , Volker Schluter
IPC: C12Q1/68
CPC classification number: G01N33/57492 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G06F19/22
Abstract: The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
Abstract translation: 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。
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